Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Journal Articles The World Journal of Men's Health Year : 2023

Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data

Rossella Cannarella (1, 2) , Rupin Shah (3) , Taha Abo-Almagd Abdel-Meguid Hamoda (4, 5) , Florence Boitrelle (6, 7) , Ramadan Saleh (8) , Murat Gul (9) , Amarnath Rambhatla (10) , Parviz Kavoussi , Tuncay Toprak (11) , Ahmed M Harraz (12) , Edmund Ko (13) , Gökhan Çeker , Damayanthi Durairajanayagam (14) , Noora Alkahidi , Shinnosuke Kuroda (2, 15) , Andrea Crafa (1) , Ralf Henkel (16) , Gianmaria Salvio (17) , Berk Hazir (18) , Mahsa Darbandi (19) , Marion Bendayan (6, 7) , Sara Darbandi (19) , Marco Falcone (20) , Nicolas Garrido , Raghavender Kosgi , Raneen Sawaid Sawaid Kaiyal (2) , Keshab Karna (21) , Nguyen Ho Vinh Phuoc (22) , Ponco Birowo (23) , Giovanni M Colpi , Jean de la Rosette (24) , Germar-Michael Pinggera (25) , Quang Nguyen (26) , Armand Zini (27) , Wael Zohdy (28) , Rajender Singh , Pallavi Saini , Sidney Glina , Haocheng Lin (29) , Taymour Mostafa (28) , Cesar Rojas-Cruz (30) , Mohamed Arafa (28, 2, 31, 32) , Aldo E Calogero (1) , Fotios Dimitriadis (33) , Priyank Kothari , Vilvapathy Senguttuvan Karthikeyan (34) , Keisuke Okada (35) , Koji Chiba (35) , Ates Kadıoglu (36) , Baris Altay (37) , Tahsin Turunc , Birute Zilaitiene , Fatih Gokalp (38) , Aram Adamyan , Darren Katz (39) , Eric Chung (40) , Tiago Cesar Mierzwa , Daniel Suslik Zylbersztejn (41) , Gustavo Marquesine Paul (42) , Nikolaos Sofikitis (43) , Ioannis Sokolakis (33) , Vineet Malhotra , Sakti Ronggowardhana Brodjonegoro (44) , Ricky Adriansjah (45) , Akira Tsujimura (46) , Toshiyasu Amano , Giancarlo Balercia (17) , Imad Ziouziou (47) , Isaac Ardianson Deswanto , Marlon Martinez (48) , Hyun Jun Park (49) , Mustafa Emre Bakırcıoglu , Erman Ceyhan , Kaan Aydos (50) , Jonathan Ramsay (51) , Suks Minhas , Manaf Al Hashimi (52) , Ramy Abou Ghayda (53) , Nicholas Tadros (54) , Puneet Sindhwani (55) , Christopher C K Ho (56) , Rinaldo Indra Rachman (23) , Marcelo Rodriguez Pena , Ahmad Motawi (28) , Arun Karthik Ponnusamy , Satish Dipankar , Azwar Amir , Saleh Binsaleh (57) , Ege Can Serefoglu (58) , Ravi Banthia (59) , Kareim Khalafalla (60, 61, 62) , Ari Basukarno , Nguyen Hoai Bac (63) , Karun Singla , Rafael F Ambar , Konstantinos Makarounis , Shivam Priyadarshi , Gede Wirya Kusuma Duarsa , Widi Atmoko (23) , Sunil Jindal , Eko Arianto , Hamed Akhavizadegan (64) , Haitham El Bardisi (60, 32) , Ohad Shoshany (65) , Gian Maria Busetto (66) , Mohamad Moussa (67) , Mounir Jamali , Mohamed S Al-Marhoon (68) , Mikhail Ruzaev , Hasan M A Farsi (4) , Shingai Mutambirwa (69) , Dong Sup Lee (70) , Deniz Kulaksiz , Yu-Sheng Cheng (71) , Abderrazak Bouzouita (72) , Selcuk Sarikaya (50) , Hussein Kandil , Georgios Tsampoukas (73) , Ala’a Farkouh , Kasonde Bowa (74) , Missy Savira (23) , Nasser Mogharabian (75) , Tan V Le (22) , Maruto Harjanggi , Dang Tuan Anh , Tran Quang Tien Long , Mohammad Ayodhia Soebadi (76) , Lukman Hakim (76) , Marko Tanic , Umut Cagin Ari (77) , Firuza R Parikh (78) , Gokhan Calik (24) , Vinod Kv , Gyem Dorji , Andri Rezano (76, 45) , Osvaldo Rajmil (79) , Dung Mai Ba Tien , Yiming Yuan (29) , Juan Francisco Lizarraga-Salas , Balantine Eze (80) , Kay Seong Ngoo , Joe Lee (81) , Umut Arslan (11) , Ashok Agarwal (74, 2)
1 Unict - Università degli studi di Catania = University of Catania
2 Cleveland Clinic
3 Lilavati Hospital and Research Centre
4 King Abdulaziz University
5 Minia University
6 CHI Poissy-Saint-Germain
7 BREED - Biologie de la Reproduction, Environnement, Epigénétique & Développement
8 Sohag University
9 Faculty of Medicine [Selcuk University Konya, Turkey]
10 Vattikuti Urology Institute
11 İstanbul Fatih Sultan Mehmet Eğitim ve Araştırma Hastanesi
12 Mansoura University [Egypt]
13 Loma Linda University
14 UiTM - Universiti Teknologi MARA [Shah Alam]
15 YCU - Yokohama City University
16 Imperial College London
17 UNIVPM - Polytechnic University of Marche [Ancona, Italy] / Università Politecnica delle Marche [Ancona, Italia]
18 Skane University Hospital [Lund]
19 Hope Generation Foundation
20 Molinette Hospital
21 UMASS - University of Massachusetts Medical School [Worcester]
22 University of Medicine Pham Ngoc Thach
23 UI - Universitas Indonesia
24 Istanbul Medipol University
25 IMU - Innsbruck Medical University = Medizinische Universität Innsbruck
26 VNU - Vietnam National University [Hanoï]
27 McGill University = Université McGill [Montréal, Canada]
28 Cairo University
29 Peking University [Beijing]
30 University Hospital Rostock
31 Hamad medical corporation
32 Weill Cornell Medicine [Qatar]
33 Aristotle University of Thessaloniki
34 Apollo Hospital, Bilaspur(C. G.), India
35 Kobe University
36 Istanbul University
37 Ege university
38 Hatay Mustafa Kemal University
39 University of Melbourne
40 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
41 Hospital Israelita Albert Einstein [São Paulo, Brazil]
42 UFPR - Universidade Federal do Paraná [Curitiba, Brasil] = Federal University of Paraná [Curitiba, Brazil] = Université fédérale du Paraná [Curitiba, Brésil]
43 University of Ioannina
44 Universitas Gadjah Mada
45 UnPad - Universitas Padjadjaran = Padjadjaran University
46 Juntendo University
47 Université Ibn Zohr [Agadir]
48 University of Santo Tomas [Manila, Philippines]
49 PNU - Pusan National University
50 Ankara University School of Medicine [Turkey]
51 Hammersmith Hospital NHS Imperial College Healthcare
52 Burjeel Hospital
53 Case Western Reserve University [Cleveland]
54 Southern Illinois University School of Medicine
55 University of Toledo
56 Taylor’s University
57 KSU - King Saud University [Riyadh]
58 Biruni University
59 Western General Hospital [Edinburgh, UK]
60 Hamad Medical Corporation [Doha, Qatar]
61 McGovern Medical School [Houston, Texas]
62 MD Anderson Cancer Center [Houston]
63 Hanoï Medical University
64 TUMS - Tehran University of Medical Sciences
65 UIC - University of Illinois [Chicago]
66 Unifg - Università degli Studi di Foggia = University of Foggia
67 LU / ULB - الجامعة اللبنانية [بيروت] = Lebanese University [Beirut] = Université libanaise [Beyrouth]
68 SQU - Sultan Qaboos University
69 SMU - Sefako Makgatho Health Sciences University - Université des sciences de la santé Sefako Makgatho
70 Catholic University of Korea
71 NCKU - National Cheng Kung University
72 Faculte De Medecine De Tunis, Universite De Tunis El Manar, LR18ES39, Tunis, Tunisia
73 John Radcliffe Hospital [Oxford University Hospital]
74 UNZA - University of Zambia [Lusaka]
75 Shahroud University of Medical Sciences
76 UNAIR - Universitas Airlangga
77 Kafkas University
78 Jaslok Hospital & Research Centre
79 Fundació Puigvert [Barcelona, Spain]
80 Department of Medical Biochemistry, College of Medicine, University of Nigeria, Enugu Campus (UNEC) Enugu, Nigeria
81 National University Hospital Singapore
Rossella Cannarella
Università degli studi di Catania = University of Catania
Cleveland Clinic
Rupin Shah
Lilavati Hospital and Research Centre
Taha Abo-Almagd Abdel-Meguid Hamoda
King Abdulaziz University
Minia University
Florence Boitrelle
CHI Poissy-Saint-Germain
Biologie de la Reproduction, Environnement, Epigénétique & Développement
CV
Ramadan Saleh
Sohag University
Murat Gul
Faculty of Medicine [Selcuk University Konya, Turkey]
Amarnath Rambhatla
Vattikuti Urology Institute
Parviz Kavoussi
Tuncay Toprak
İstanbul Fatih Sultan Mehmet Eğitim ve Araştırma Hastanesi
Ahmed M Harraz
Mansoura University [Egypt]
Edmund Ko
Loma Linda University
Gökhan Çeker
Damayanthi Durairajanayagam
Universiti Teknologi MARA [Shah Alam]
Noora Alkahidi
Shinnosuke Kuroda
Cleveland Clinic
Yokohama City University
Andrea Crafa
Università degli studi di Catania = University of Catania
Ralf Henkel
Imperial College London
Gianmaria Salvio
Polytechnic University of Marche [Ancona, Italy] / Università Politecnica delle Marche [Ancona, Italia]
Berk Hazir
Skane University Hospital [Lund]
Mahsa Darbandi
Hope Generation Foundation
Marion Bendayan
CHI Poissy-Saint-Germain
Biologie de la Reproduction, Environnement, Epigénétique & Développement
CV
Sara Darbandi
Hope Generation Foundation
Marco Falcone
Molinette Hospital
Nicolas Garrido
Raghavender Kosgi
Raneen Sawaid Sawaid Kaiyal
Cleveland Clinic
Keshab Karna
University of Massachusetts Medical School [Worcester]
Nguyen Ho Vinh Phuoc
University of Medicine Pham Ngoc Thach
Ponco Birowo
Universitas Indonesia
Giovanni M Colpi
Jean de la Rosette
Istanbul Medipol University
Germar-Michael Pinggera
Innsbruck Medical University = Medizinische Universität Innsbruck
Quang Nguyen
Vietnam National University [Hanoï]
Armand Zini
McGill University = Université McGill [Montréal, Canada]
Wael Zohdy
Cairo University
Rajender Singh
Pallavi Saini
Sidney Glina
Haocheng Lin
Peking University [Beijing]
Taymour Mostafa
Cairo University
Cesar Rojas-Cruz
University Hospital Rostock
Mohamed Arafa
Cairo University
Cleveland Clinic
Hamad medical corporation
Weill Cornell Medicine [Qatar]
Aldo E Calogero
Università degli studi di Catania = University of Catania
Fotios Dimitriadis
Aristotle University of Thessaloniki
Priyank Kothari
Vilvapathy Senguttuvan Karthikeyan
Apollo Hospital, Bilaspur(C. G.), India
Keisuke Okada
Kobe University
Koji Chiba
Kobe University
Ates Kadıoglu
Istanbul University
Baris Altay
Ege university
Tahsin Turunc
Birute Zilaitiene
Fatih Gokalp
Hatay Mustafa Kemal University
Aram Adamyan
Darren Katz
University of Melbourne
Eric Chung
The University of Queensland
Tiago Cesar Mierzwa
Daniel Suslik Zylbersztejn
Hospital Israelita Albert Einstein [São Paulo, Brazil]
Gustavo Marquesine Paul
Universidade Federal do Paraná [Curitiba, Brasil] = Federal University of Paraná [Curitiba, Brazil] = Université fédérale du Paraná [Curitiba, Brésil]
Nikolaos Sofikitis
University of Ioannina
Ioannis Sokolakis
Aristotle University of Thessaloniki
Vineet Malhotra
Sakti Ronggowardhana Brodjonegoro
Universitas Gadjah Mada
Ricky Adriansjah
Universitas Padjadjaran = Padjadjaran University
Akira Tsujimura
Juntendo University
Toshiyasu Amano
Giancarlo Balercia
Polytechnic University of Marche [Ancona, Italy] / Università Politecnica delle Marche [Ancona, Italia]
Imad Ziouziou
Université Ibn Zohr [Agadir]
Isaac Ardianson Deswanto
Marlon Martinez
University of Santo Tomas [Manila, Philippines]
Hyun Jun Park
Pusan National University
Mustafa Emre Bakırcıoglu
Erman Ceyhan
Kaan Aydos
Ankara University School of Medicine [Turkey]
Jonathan Ramsay
Hammersmith Hospital NHS Imperial College Healthcare
Suks Minhas
Manaf Al Hashimi
Burjeel Hospital
Ramy Abou Ghayda
Case Western Reserve University [Cleveland]
Nicholas Tadros
Southern Illinois University School of Medicine
Puneet Sindhwani
University of Toledo
Christopher C K Ho
Taylor’s University
Rinaldo Indra Rachman
Universitas Indonesia
Marcelo Rodriguez Pena
Ahmad Motawi
Cairo University
Arun Karthik Ponnusamy
Satish Dipankar
Azwar Amir
Saleh Binsaleh
King Saud University [Riyadh]
Ege Can Serefoglu
Biruni University
Ravi Banthia
Western General Hospital [Edinburgh, UK]
Kareim Khalafalla
Hamad Medical Corporation [Doha, Qatar]
McGovern Medical School [Houston, Texas]
MD Anderson Cancer Center [Houston]
Ari Basukarno
Nguyen Hoai Bac
Hanoï Medical University
Karun Singla
Rafael F Ambar
Konstantinos Makarounis
Shivam Priyadarshi
Gede Wirya Kusuma Duarsa
Widi Atmoko
Universitas Indonesia
Sunil Jindal
Eko Arianto
Hamed Akhavizadegan
Tehran University of Medical Sciences
Haitham El Bardisi
Hamad Medical Corporation [Doha, Qatar]
Weill Cornell Medicine [Qatar]
Ohad Shoshany
University of Illinois [Chicago]
Gian Maria Busetto
Università degli Studi di Foggia = University of Foggia
Mohamad Moussa
الجامعة اللبنانية [بيروت] = Lebanese University [Beirut] = Université libanaise [Beyrouth]
Mounir Jamali
Mohamed S Al-Marhoon
Sultan Qaboos University
Mikhail Ruzaev
Hasan M A Farsi
King Abdulaziz University
Shingai Mutambirwa
Sefako Makgatho Health Sciences University - Université des sciences de la santé Sefako Makgatho
Dong Sup Lee
Catholic University of Korea
Deniz Kulaksiz
Yu-Sheng Cheng
National Cheng Kung University
Abderrazak Bouzouita
Faculte De Medecine De Tunis, Universite De Tunis El Manar, LR18ES39, Tunis, Tunisia
Selcuk Sarikaya
Ankara University School of Medicine [Turkey]
Hussein Kandil
Georgios Tsampoukas
John Radcliffe Hospital [Oxford University Hospital]
Ala’a Farkouh
Kasonde Bowa
University of Zambia [Lusaka]
Missy Savira
  • Function : Author
Universitas Indonesia
Nasser Mogharabian
Shahroud University of Medical Sciences
Tan V Le
University of Medicine Pham Ngoc Thach
Maruto Harjanggi
Dang Tuan Anh
Tran Quang Tien Long
Mohammad Ayodhia Soebadi
Universitas Airlangga
Lukman Hakim
Universitas Airlangga
Marko Tanic
Umut Cagin Ari
Kafkas University
Firuza R Parikh
Jaslok Hospital & Research Centre
Gokhan Calik
Istanbul Medipol University
Vinod Kv
Gyem Dorji
Andri Rezano
Universitas Airlangga
Universitas Padjadjaran = Padjadjaran University
Osvaldo Rajmil
Fundació Puigvert [Barcelona, Spain]
Dung Mai Ba Tien
Yiming Yuan
Peking University [Beijing]
Juan Francisco Lizarraga-Salas
Balantine Eze
Department of Medical Biochemistry, College of Medicine, University of Nigeria, Enugu Campus (UNEC) Enugu, Nigeria
Kay Seong Ngoo
Joe Lee
National University Hospital Singapore
Umut Arslan
İstanbul Fatih Sultan Mehmet Eğitim ve Araştırma Hastanesi
Ashok Agarwal
University of Zambia [Lusaka]
Cleveland Clinic

Abstract

Purpose: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles. Materials and methods: The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies). Results: Out of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were included in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129-0.278; p<0.001; I²=83.62%, Egger's p=0.3329; sperm concentration: SMD 1.590, 95% CI: 1.474-1.706; p<0.001; I²=97.86%, Egger's p<0.0001; total sperm count: SMD 1.824, 95% CI: 1.526-2.121; p<0.001; I²=97.88%, Egger's p=0.0063; total motile sperm count: SMD 1.643, 95% CI: 1.318-1.968; p<0.001; I²=98.65%, Egger's p=0.0003; progressive sperm motility: SMD 1.845, 95% CI: 1.537%-2.153%; p<0.001; I²=98.97%, Egger's p<0.0001; total sperm motility: SMD 1.613, 95% CI 1.467%-1.759%; p<0.001; l2=97.98%, Egger's p<0.001; sperm morphology: SMD 1.066, 95% CI 0.992%-1.211%; p<0.001; I²=97.87%, Egger's p=0.1864. Conclusions: The current meta-analysis is the largest to date using paired analysis on varicocele patients. In the current meta-analysis, almost all conventional semen parameters improved significantly following varicocele repair in infertile patients with clinical varicocele.

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Reproductive Biology
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Submitted on : Monday, July 3, 2023-4:36:05 PM

Last modification on : Wednesday, September 25, 2024-5:22:04 PM

Long-term archiving on : Thursday, October 5, 2023-9:49:31 AM

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hal-04149299 , version 1 (03-07-2023)

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Rossella Cannarella, Rupin Shah, Taha Abo-Almagd Abdel-Meguid Hamoda, Florence Boitrelle, Ramadan Saleh, et al.. Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data. The World Journal of Men's Health, 2023, 41, ⟨10.5534/wjmh.230034⟩. ⟨hal-04149299⟩

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