Global branches and local states of the human gut microbiome define associations with environmental and intrinsic factors - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Journal Articles Nature Communications Year : 2023

Global branches and local states of the human gut microbiome define associations with environmental and intrinsic factors

Abstract

The gut microbiome is important for human health, yet modulation requires more insight into inter-individual variation. Here, we explored latent structures of the human gut microbiome across the human lifespan, applying partitioning, pseudotime, and ordination approaches to >35,000 samples. Specifically, three major gut microbiome branches were identified, within which multiple partitions were observed in adulthood, with differential abundances of species along branches. Different compositions and metabolic functions characterized the branches’ tips, reflecting ecological differences. An unsupervised network analysis from longitudinal data from 745 individuals showed that partitions exhibited connected gut microbiome states rather than over-partitioning. Stability in the Bacteroides -enriched branch was associated with specific ratios of Faecalibacterium:Bacteroides . We also showed that associations with factors (intrinsic and extrinsic) could be generic, branch- or partition-specific. Our ecological framework for cross-sectional and longitudinal data allows a better understanding of overall variation in the human gut microbiome and disentangles factors associated with specific configurations.
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Dates and versions

hal-04159501 , version 1 (15-09-2024)

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Julien Tap, Franck Lejzerowicz, Aurélie Cotillard, Matthieu Pichaud, Daniel Mcdonald, et al.. Global branches and local states of the human gut microbiome define associations with environmental and intrinsic factors. Nature Communications, 2023, 14 (1), pp. 3310. ⟨10.1038/s41467-023-38558-7⟩. ⟨hal-04159501⟩

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