Influence of Trimetazidine on the synthesis of complex lipids in the heart and other target organs - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Fundamental & Clinical Pharmacology Year : 2001

Influence of Trimetazidine on the synthesis of complex lipids in the heart and other target organs

Abstract

Trimetazidine (TMZ, 1-[2,3,4-trimethoxy-benzyl] piperazine, 2 HCl), which was introduced as an antianginal drug 20 years ago, exerts its properties at the cellular level, without haemodynamic effects in clinical conditions [1±3]. Bricaud et al. [4] demonstrated the bene®cial effect of a long-term TMZ treatment in ischemic cardiopathy without associated adverse effects. In vitro, the bene®cial properties of the molecule were reported in isolated perfused heart models, which con®rmed that the mechanism of the bene®cial effect was not associated to any haemodynamic component [5,6]. Using a similar model, Lavanchy et al. [7] showed that during a global normothermic ischemia, TMZ prevented acidosis and inorganic phosphate accumulation and increased the recovery of adenosine triphosphate (ATP) at reperfusion. Similar results were obtained on cardiomyocyte cultures Keywords angina,
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Dates and versions

hal-04202570 , version 1 (11-09-2023)

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E. Sentex, Cécile Héliès-Toussaint, D. Rousseau, A. Lucien, E. Ferrary, et al.. Influence of Trimetazidine on the synthesis of complex lipids in the heart and other target organs. Fundamental & Clinical Pharmacology, 2001, 15 (4), pp.255 - 264. ⟨10.1046/j.1472-8206.2001.00031.x⟩. ⟨hal-04202570⟩
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