Using mouse genetics to investigate thyroid hormone signaling in the developing and adult brain.
Résumé
The developing and adult brain is a main target organ of thyroid hormones
(including the prohormone thyroxine and its active derivative tri-iodothyronine
or T3). Mouse genetics offers a number of promising possibilities to study
their pleiotropic infl uence on the central nervous system, and to distinguish it from
their peripheral function. In the following, we review recent advances brought by
mouse genetics in our understanding of thyroid hormone signaling in the brain, both
during development and in the adult. We particularly emphasize on the latest fi ndings
about thyroid hormone transporters and synthesis pathway which bring a new
view on the regulation of thyroid hormone levels sensed by brain cells. Roles of the
thyroid hormone receptors, which have been reviewed elsewhere are only briefly
discussed.
Domaines
Biologie moléculaire
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Chatonnet_Koibuchi2016ThyroidHormoneDisruptionNeurodev.pdf (5 Mo)
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