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Conference Papers Year : 2023

Branches and ecological states of the gut microbiome: Mapping for future personalized nutritional and therapeutic interventions

Abstract

The gut microbiome is crucial for health, but understanding its modulation is complex due to high inter-individual variation. Recent studies reveal that environmental and host factors account for less than 20% of microbial composition variation, highlighting the importance of stochastic factors and ecological rules. While diet and lifestyle impact the host-microbiome relationship, resilience is key in maintaining its structure over a lifetime. Our analysis of 35,000 gut samples showed the microbiome as branch-structured, with different states connected to host and environmental factors. This structure can identify transitions to less healthy states linked with diversity and function changes. Next-gen engines may need to consider identified gut-tipping elements to prevent reaching unhealthy states. Thinking of the microbiome as branch-connected ecological states paves the way more than ever for personalized nutritional and therapeutic interventions.
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hal-04316201 , version 1 (30-11-2023)

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  • HAL Id : hal-04316201 , version 1

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Julien Tap. Branches and ecological states of the gut microbiome: Mapping for future personalized nutritional and therapeutic interventions. Journées Polepharma de Microbiomique, Polepharma, Nov 2023, Rouen, France. ⟨hal-04316201⟩
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