Role of Chinook salmon PKR and PERK in protein translation inhibition during Golden Shiner Virus infection - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Conference Poster Year : 2023

Role of Chinook salmon PKR and PERK in protein translation inhibition during Golden Shiner Virus infection

Abstract

The interferon-induced antiviral response is mediated through a wide range of interferon-stimulated genes (ISGs). The double-stranded RNA-activated protein kinase R (PKR) is one of the most studied proteins encoded by an ISG and is recognized as a multifunctional key factor of innate immunity. In mammals and in fish, it is known to be involved in cellular processes in response to stress signals, including inhibition of protein translation initiation via phosphorylation of the eukaryotic initiation factor 2α (eIF2α).
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hal-04582374 , version 1 (21-05-2024)

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  • HAL Id : hal-04582374 , version 1

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Lise. Chaumont, Mathilde Peruzzi, Pierre Boudinot, Bertrand Collet. Role of Chinook salmon PKR and PERK in protein translation inhibition during Golden Shiner Virus infection. 21st International Conference on Diseases of Fish and Shellfish, European Association of Fish Pathologists (EAFP), Sep 2023, Aberdeen, United Kingdom. ⟨hal-04582374⟩
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