Secondary loop architectures and phase change material (PCM) slurries could reduce the environmental impact of refrigeration and air-conditioning systems by lowering significantly the amount of primary refrigerants. However, there is a barrier to their industrial development due to the lack of studies on their behaviour in operational scenarios. The present work analyses the behaviour of different secondary loop systems in an industrial context, here the air conditioning of a supermarket in France. For this purpose, a generic approach, developed in previous work, is proposed to assess their potential of adoption. This modelling approach is able to describe the sustainability and operational performance (energy, environmental, economic, social) of refrigeration systems. After validation of the model on real architecture and components, five standard or new architectures were tested: centralized direct expansion system; secondary loop system with ethylene glycol water; secondary loop system with ice slurries, TBPB hydrate slurries or CO2 hydrate slurries. The main results of this study show that new secondary systems using hydrate slurries have better cooling energy performance than direct expansion or classical brine / ice slurry secondary systems. Moreover, even including pumping power, the life cycle climate performance of secondary loop systems is much better than that of direct expansion systems. However, the total cost of ownership of direct expansion systems is lower than that of secondary systems, but with little differences for smaller pipes. Finally, trade-offs between several performances can be proposed. For example, some architectures with suitable pipe diameters could meet TCO/LCCP-based and CAPEX/pumping-based trade-offs.