Onosma safaie-fari (of O. subsect. Asterotricha) is described as a new species from western Iran. Onosma safaiefari is morphologically similar to O. iranshahrii, but it is distinct in terms of the shape of sterile shoots and cauline leaves; length of fruiting calyx, shape, and width of calyx lobes; and color of the corolla. In addition, O. safaie-fari is similar to O. bisotunensis, but it is distinguished by the shape and length of lower bracts; length of the fruiting calyx; color and length of the corolla; length of the free part of filaments; the position of filaments arising from the corolla, and length of anthers. Onosma safaie-fari is close to O. shehbazii, but it can be distinguished from it based on the shape and length of sterile shoots and cauline leaves, length of lower bracts, length of fruiting calyx, color and length of the corolla, length of anthers, and the presence of a hairy nectary ring. Detailed descriptions, diagnostic characters, original photographs, illustrations, a geographical distribution map, habitat information, an image of the holotype specimen, and an identification key are presented.