Calcium-rich dairy matrix protects better than mineral calcium against colonic luminal haem-induced alterations in male rats - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles npj Science of Food Year : 2024

Calcium-rich dairy matrix protects better than mineral calcium against colonic luminal haem-induced alterations in male rats

Maïwenn Olier
Ingrid Ahn
  • Function : Author
Nadine Leconte
Gilles Garric
Gwénaël Jan

Abstract

The haemoglobin content in meat is consistently associated with an increased risk of colorectalcancer, whereas calcium may play a role as a chemopreventive agent. Using rodent models, calciumsalts have been shown to prevent the promotion of haem-induced and red meat-induced colorectalcarcinogenesis by limiting the bioavailability of the gut luminal haem iron. Therefore, this study aimedto compare impacts of dietary calcium provided as calcium salts or dairy matrix on gut homoeostasisperturbations by high haeminic or non-haeminic iron intakes. A 3-week intervention study wasconducted using Fischer 344 rats. Compared to the ferric citrate-enriched diet, the haemoglobin-enriched diet led to increased faecal, mucosal, and urinary lipoperoxidation-related biomarkers,resulting from higher gut luminal haem iron bioavailability. This redox imbalance was associated to adysbiosis of faecal microbiota. The addition of calcium to haemoglobin-enriched diets limited haemiron bioavailability and counteracted redox imbalance, with improved preventive efficacy whencalcium was provided in dairy matrix. Data integration revealed correlations between haem-inducedlipoperoxidation products and bacterial communities belonging to Peptococcaceae, Eubacteriumcoprostanoligenes group, and Bifidobacteriaceae. This integrated approach provides evidence of thebenefits of dairy matrix as a dietary calcium vehicle to counteract the deleterious side-effects of meatconsumption.
Fichier principal
Vignette du fichier
s41538-024-00273-y.pdf (2.88 Mo) Télécharger le fichier
Origin Files produced by the author(s)
Licence

Dates and versions

hal-04633730 , version 1 (03-07-2024)

Licence

Identifiers

Cite

Maïwenn Olier, Nathalie Naud, Edwin Fouché, Valérie Tondereau, Ingrid Ahn, et al.. Calcium-rich dairy matrix protects better than mineral calcium against colonic luminal haem-induced alterations in male rats. npj Science of Food, 2024, 8, ⟨10.1038/s41538-024-00273-y⟩. ⟨hal-04633730⟩
0 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More