Polystyrene nanoplastics disrupt hepatic vitellogenin metabolism and impairs the reproduction process in female zebrafish - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Journal Articles Annals of Animal Science Year : 2024

Polystyrene nanoplastics disrupt hepatic vitellogenin metabolism and impairs the reproduction process in female zebrafish

Abstract

Abstract For this study, a number of 240 adult healthy female zebrafish were divided into 12 tanks (20 fish per tank) and exposed to 0 (control, T0), 0.1 (T1), 1 (T2), and 10 (T3) mg/L synthesized polystyrene nanoplastics (PS-NPs, Nanoplastic synthesized in the chemistry laboratory of Faculty of Basic Sciences at Zabul University) for 4 weeks. At the end of the experiment, exposure to PS-NPs had no significant affect the survival of female zebrafish (p > 0.05). A significant decrease of hepatic vitellogenin (Vtg) were seen in female zebrafish exposed to PSNPs (p < 0.05). The level of 17β estradiol (E2) and testosterone (T) were notably declined in female zebrafish of all PS-NPs-exposed groups (p < 0.05). Glucose was notably increased in female zebra fish of all PS-NPs-exposed treaments (p < 0.05). There was a significant increase in cortisol levels in all PS-NPs-exposed treaments (p < 0.05). No significant diffrenece was seen in lactate levels between different treatments (p > 0.05). A significant enhancement in aspartate aminotransferase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) was observed in female zebra fish of all PS-NPs-exposed treaments than the control (p < 0.05). The present results demonstrate that PS-NPs impairs the reproduction process so that none of the female zebrafish broodstock exposed to different doses of PS-NPs have not spawn.

Dates and versions

hal-04644493 , version 1 (11-07-2024)

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Sedigheh Mohammadzadeh, Amine Zaretabar, Ehsan Ahmadifar, Mostafa Khajeh, Mohsen Shahriari Moghadam, et al.. Polystyrene nanoplastics disrupt hepatic vitellogenin metabolism and impairs the reproduction process in female zebrafish. Annals of Animal Science , 2024, ⟨10.2478/aoas-2024-0022⟩. ⟨hal-04644493⟩
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