Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Journal Articles Nature Communications Year : 2024

Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation

Nils J Færgeman
Vyacheslav Akimov
Blagoy Blagoev
Betina Elfving
Ditte Neess

Abstract

The fetal development of organs and functions is vulnerable to perturbation by maternal inflammation which may increase susceptibility to disorders after birth. Because it is not well understood how the placenta and fetus respond to acute lung- inflammation, we characterize the response to maternal pulmonary lipopolysaccharide exposure across 24 h in maternal and fetal organs using multi-omics, imaging and integrative analyses. Unlike maternal organs, which mount strong inflammatory immune responses, the placenta upregulates immuno-modulatory genes, in particular the IL-6 signaling suppressor Socs3. Similarly, we observe no immune response in the fetal liver, which instead displays metabolic changes, including increases in lipids containing docosahexaenoic acid, crucial for fetal brain development. The maternal liver and plasma display similar metabolic alterations, potentially increasing bioavailability of docosahexaenoic acid for the mother and fetus. Thus, our integrated temporal analysis shows that systemic inflammation in the mother leads to a metabolic perturbation in the fetus.
Fichier principal
Vignette du fichier
41467_2024_Article_48492.pdf (5.96 Mo) Télécharger le fichier
Origin Publisher files allowed on an open archive
Licence

Dates and versions

hal-04645469 , version 1 (11-07-2024)

Licence

Identifiers

Cite

Signe Schmidt Kjølner Hansen, Robert Krautz, Daria Rago, Jesper Havelund, Arnaud Stigliani, et al.. Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation. Nature Communications, 2024, 15, ⟨10.1038/s41467-024-48492-x⟩. ⟨hal-04645469⟩
90 View
14 Download

Altmetric

Share

More