Grain legumes are major key players of the agro-ecological and food transitions due to their nitrogen-fixing and diversifying qualities in cropping systems and their protein-rich seeds. However, grain legumes are susceptible to multiple diseases and pests, generating high crop yield instabilities. Aphanomyces root rot, Ascochyta blight, and seed weevils have been the most damaging and studied stresses in France over the past 20 years. Other pests, including weeds, aphids and sitona, are currently becoming problematic for grain legumes in the light of new regulations on pesticide use. Breeding varieties for multi-pest resistance is a major challenge for grain legume development. A major objective of the French national SPECIFICS (2021-2027) project is to generate and integrate knowledge on the diversity, genetics, genomics and mechanisms of resistance to multiple pests and protective traits in grain legumes. A Grin-Global database is deployed to manage the pea and faba bean INRAE genetic resources. Automated or manual phenotyping of exome sequenced pea or faba bean collections is performed for seedling emergence, response to water deficit, plant root and nodule architecture and aphid resistance. A NoSQL graph database is developed to integrate QTL, RNASeq and gene annotation data in five legume species. The data base will connect data obtained in the project or previously for resistance to diseases and pests (A. euteiches, D. pinodes, Bruchus spp., A. pisum and A. fabae), seedling establishment and pest or disease-related root/aerial architectural traits to identify putative pleiotropic or syntenic genes. Pea mutant lines in susceptibility genes conserved from other plant species and speed breeding introgression lines are produced to identify and combine genes and loci for multi-pest resistance. Results will provide new knowledge and tools to accelerate breeding of grain legume varieties for pesticide-free cropping systems.