CORE GUT MICROBIOTA IN RABBIT: OPPORTUNITIES TO STRENGTHEN THE INTESTINAL BARRIER - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Conference Papers Year : 2024

CORE GUT MICROBIOTA IN RABBIT: OPPORTUNITIES TO STRENGTHEN THE INTESTINAL BARRIER

Abstract

The symbiotic relationship between the intestinal microbiota and its host is crucial to the development and functioning of both partners. The microbiota plays a key role in the development and physiology of its host (nutrition, growth, health, and cognition). In turn, the host shapes the microbiota, according to factors that are intrinsic or dependent on its environment. However, the definition of an optimal microbiota that maximises ecosystem services (host benefits) has yet not be established. The symbiotic relationship between the microbiota and its host is based on a complex molecular dialogue at the level of the intestinal epithelium and the underlying mucosal immune system. These interactions condition the establishment of an intestinal barrier, limiting colonisation by microbial pathogens and thereby guaranteeing health. In this review, we propose a 'core' rabbit microbiota definition through a re-analysis of available open-source data. Based on the association between the abundance of bacterial taxa and host traits, we attempt to identify microbiota key species that would likely be involved in growth performance and health. Then, we describe the components of the intestinal barrier and the host-microbiota interaction mechanisms. Finally, we propose early in life nutritional levers to strengthen this intestinal barrier and thereby enhance the health of young rabbits before weaning.
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Dates and versions

hal-04754818 , version 1 (26-10-2024)

Identifiers

  • HAL Id : hal-04754818 , version 1

Cite

Sylvie Combes, Mathilde Rumeau, Charlotte Paës, Géraldine Pascal, Cláudia M. Vicente, et al.. CORE GUT MICROBIOTA IN RABBIT: OPPORTUNITIES TO STRENGTHEN THE INTESTINAL BARRIER. 13th World Rabbit Congress, WRSA, Oct 2024, Tarragona, Spain, Spain. pp.BP24-BP48. ⟨hal-04754818⟩
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