Preserving the genetic resources of diverse biomes is essential in the context of global climate change and biodiversity erosion. Capturing epigenomic referential picture times in longitudinal research programs will allow retrospective studies to unravel the molecular mechanisms at stake in species adaptation to global warming and environmental changes such as pollution, food, the emergence of pathogens, or resistance.Biomolecules will be stored as a patrimonial legacy to the next generations to anticipate the co-evolution of research fields (epigenetics, eDNA, nc RNA, etc.), holistic dimensions (pangenome, holobionte), and technologies (NGS and IA). Moreover, compared to classical freezing conditions, biomolecules will be stored at ambient temperature to fulfil CSR goals.The pilot experiment includes various environmental DNA matrices, from very low (eDNA) to high molecular weight (plancton, salmon, pig). We selected three promising RT storage technologies based on their reusable and scalable properties. Aging of the stored DNA samples will be accelerated based on the Arrhenius equation. Comparison of storage conditions will be assessed by full DNA quality control, short-and/or-long reads sequencing and analysis of; deamination, metabarcoding, metagenomic, WGS and methylome will be performed.The CSR DNA-library project, led by the environment pillar of the French Research Infrastructure RARe, brings together the resources and expertise of French genomics and bioinformatics Infrastructures, France Genomique.