P. Gregersen, J. Silver, and R. Winchester, The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis, Arthritis & Rheumatism, vol.4, issue.11, pp.1205-1213, 1987.
DOI : 10.1002/art.1780301102

J. Meyer, J. Han, R. Singh, and G. Moxley, Sex influences on the penetrance of HLA shared-epitope genotypes for rheumatoid arthritis, Am J Hum Genet, vol.58, pp.371-383, 1996.

E. Génin, M. Babron, M. Mcdermott, B. Mulcahy, F. Waldron-lynch et al., Modelling the major histocompatibility complex susceptibility to RA using the MASC method, Genetic Epidemiology, vol.86, issue.4, pp.419-430, 1998.
DOI : 10.1002/(SICI)1098-2272(1998)15:4<419::AID-GEPI7>3.0.CO;2-X

A. Rigby, A. Macgregor, and G. Thomson, HLA haplotype sharing in rheumatoid arthritis sibships: Risk estimates subdivided by proband genotype, Genetic Epidemiology, vol.33, issue.4, pp.403-418, 1998.
DOI : 10.1002/(SICI)1098-2272(1998)15:4<403::AID-GEPI6>3.0.CO;2-2

S. Tezenas-du-montcel, D. Reviron, E. Génin, J. Roudier, and P. Mercier, Modeling the HLA component in rheumatoid arthritis: Sensitivity to DRB1 allele frequencies, Genetic Epidemiology, vol.51, issue.4, pp.422-428, 2000.
DOI : 10.1002/1098-2272(200012)19:4<422::AID-GEPI12>3.0.CO;2-A

S. Tezenas-du-montcel, L. Michou, E. Petit-teixeira, J. Osorio, I. Lemaire et al., New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility, Arthritis & Rheumatism, vol.168, issue.4, pp.1063-1068, 2005.
DOI : 10.1002/art.20989

F. Clerget-darpoux, M. Babron, B. Prum, G. Lathrop, I. Deschamps et al., A new method to test genetic models in HLA associated diseases: the MASC method, Annals of Human Genetics, vol.21, issue.3, pp.247-258, 1988.
DOI : 10.1016/0010-4809(84)90013-2

F. Arnett, S. Edworthy, D. Bloch, D. Mcshane, J. Fries et al., The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis, Arthritis & Rheumatism, vol.143, issue.3, pp.315-324, 1988.
DOI : 10.1002/art.1780310302

S. Self, G. Longton, K. Kopecky, and K. Liang, On Estimating HLA/Disease Association with Application to a Study of Aplastic Anemia, Biometrics, vol.47, issue.1, pp.53-61, 1991.
DOI : 10.2307/2532495

H. Cordell and D. Clayton, A Unified Stepwise Regression Procedure for Evaluating the Relative Effects of Polymorphisms within a Gene Using Case/Control or Family Data: Application to HLA in Type 1 Diabetes, The American Journal of Human Genetics, vol.70, issue.1, pp.124-141, 2002.
DOI : 10.1086/338007

L. Padyukov, C. Silva, P. Stolt, L. Alfredsson, and L. Klareskog, A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis, Arthritis & Rheumatism, vol.5, issue.10, pp.3085-3092, 2004.
DOI : 10.1002/art.20553

L. Klareskog, P. Stolt, K. Lundberg, H. Kallberg, C. Bengtsson et al., A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA???DR (shared epitope)???restricted immune reactions to autoantigens modified by citrullination, Arthritis & Rheumatism, vol.16, issue.1, pp.38-46, 2006.
DOI : 10.1002/art.21575

A. Begovich, V. Carlton, L. Honigberg, S. Schrodi, A. Chokkalingam et al., A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis, The American Journal of Human Genetics, vol.75, issue.2, pp.330-337, 2004.
DOI : 10.1086/422827

P. Dieudé, S. Garnier, L. Michou, E. Petit-teixeira, E. Glikmans et al., Rheumatoid arthritis seropositive for the rheumatoid factor is linked to the protein tyrosine phosphatase nonreceptor 22?620 W allele, Arthritis Research & Therapy, vol.7, issue.6, pp.1200-1207, 2005.
DOI : 10.1186/ar1812

D. Jawaheer, W. Li, R. Graham, W. Chen, A. Damle et al., Dissecting the Genetic Complexity of the Association between Human Leukocyte Antigens and Rheumatoid Arthritis, The American Journal of Human Genetics, vol.71, issue.3, pp.585-594, 2002.
DOI : 10.1086/342407

J. Newton, S. Harney, B. Wordsworth, and M. Brown, A review of the MHC genetics of rheumatoid arthritis, Genes and Immunity, vol.5, issue.3, pp.151-157, 2004.
DOI : 10.1038/sj.gene.6364045

A. Van-der-helm-van-mil, T. Huizinga, G. Schreuder, F. Breedveld, R. De-vries et al., An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibility, Arthritis & Rheumatism, vol.2, issue.9, pp.2637-2644, 2005.
DOI : 10.1002/art.21272

D. Mattey, P. Dawes, M. Gonzalez-gay, C. Garcia-porrua, W. Thomson et al., HLA-DRB1 alleles encoding an aspartic acid at position 70 protect against development of rheumatoid arthritis, J Rheumatol, vol.28, pp.232-239, 2001.

N. De-vries, H. Tijssen, P. Van-riel, and L. Van-de-putte, Reshaping the shared epitope hypothesis: HLA-associated risk for rheumatoid arthritis is encoded by amino acid substitutions at positions 67-74 of the HLA-DRB1 molecule, Arthritis & Rheumatism, vol.32, issue.4, pp.921-928, 2002.
DOI : 10.1002/art.10210

X. Gao, N. Olsen, P. T. Stastny, and P. , Hla-dr alleles with naturally occurring amino acid substitutions and risk for development of rheumatoid arthritis, Arthritis & Rheumatism, vol.240, issue.7, pp.939-941, 1990.
DOI : 10.1002/art.1780330704

J. Gorman and L. Criswell, The shared epitope and severity of rheumatoid arthritis, Rheumatic Disease Clinics of North America, vol.28, issue.1, pp.59-78, 2002.
DOI : 10.1016/S0889-857X(03)00069-3

P. Gourraud, J. Boyer, T. Barnetche, M. Abbal, A. Cambon-thomsen et al., A new classification of HLA???DRB1 alleles differentiates predisposing and protective alleles for rheumatoid arthritis structural severity, Arthritis & Rheumatism, vol.64, issue.2, pp.593-599, 2006.
DOI : 10.1002/art.21630