C. Clarke, The pathology and pathogenesis of paratuberculosis in ruminants and other species, Journal of Comparative Pathology, vol.116, issue.3, pp.217-261, 1997.
DOI : 10.1016/S0021-9975(97)80001-1

N. Harris and R. Barletta, Mycobacterium avium subsp. paratuberculosis in Veterinary Medicine, Clinical Microbiology Reviews, vol.14, issue.3, pp.489-512, 2001.
DOI : 10.1128/CMR.14.3.489-512.2001

S. Nielsen and N. Toft, A review of prevalences of paratuberculosis in farmed animals in Europe, Preventive Veterinary Medicine, vol.88, issue.1, pp.1-14, 2009.
DOI : 10.1016/j.prevetmed.2008.07.003

S. Ott, S. Wells, and B. Wagner, Herd-level economic losses associated with Johne's disease on US dairy operations, Preventive Veterinary Medicine, vol.40, issue.3-4, pp.3-4179, 1999.
DOI : 10.1016/S0167-5877(99)00037-9

R. Smith, Y. Grohn, A. Pradhan, R. Whitlock, V. Kessel et al., A longitudinal study on the impact of Johne's disease status on milk production in individual cows, Journal of Dairy Science, vol.92, issue.6, pp.922653-2661, 2009.
DOI : 10.3168/jds.2008-1832

D. Wilson, K. Rood, P. Biswas, and T. Byrem, Herd-level prevalence of Johne's disease in Utah and adjacent areas of the intermountain west as detected by a bulk-tank milk surveillance project, Journal of Dairy Science, vol.93, issue.12, pp.935792-5797, 2010.
DOI : 10.3168/jds.2010-3481

E. Momotani, D. Whipple, A. Thiermann, and N. Cheville, into Domes of Ileal Peyer's Patches in Calves, Veterinary Pathology, vol.35, issue.2, pp.131-137, 1988.
DOI : 10.1177/030098588802500205

J. Pott, T. Basler, C. Duerr, M. Rohde, R. Goethe et al., by intestinal epithelial cells, Cellular Microbiology, vol.108, issue.12, pp.1802-1815, 2009.
DOI : 10.1111/j.1462-5822.2009.01372.x

F. Menozzi, R. Bischoff, E. Fort, M. Brennan, and C. Locht, Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin, Proceedings of the National Academy of Sciences, vol.95, issue.21, pp.9512625-12630, 1998.
DOI : 10.1073/pnas.95.21.12625

K. Pethe, S. Alonso, F. Biet, G. Delogu, M. Brennan et al., The heparin-binding haemagglutinin of M. Tuberculosis Is required for extrapulmonary dissemination, Nature, issue.6843, pp.412190-194, 2001.

K. Pethe, M. Aumercier, E. Fort, C. Gatot, C. Locht et al., Characterization of the Heparin-binding Site of the Mycobacterial Heparin-binding Hemagglutinin Adhesin, Journal of Biological Chemistry, vol.275, issue.19, pp.27514273-14280, 2000.
DOI : 10.1074/jbc.275.19.14273

K. Pethe, P. Bifani, H. Drobecq, C. Sergheraert, A. Debrie et al., Mycobacterial heparin-binding hemagglutinin and laminin-binding protein share antigenic methyllysines that confer resistance to proteolysis, Proceedings of the National Academy of Sciences, vol.99, issue.16, pp.9910759-10764, 2002.
DOI : 10.1073/pnas.162246899

C. Masungi, S. Temmerman, V. Vooren, J. Drowart, A. Pethe et al., Heparin???Binding Hemagglutinin Adhesin in Infected Healthy Individuals and Patients with Tuberculosis, The Journal of Infectious Diseases, vol.185, issue.4, pp.513-520, 2002.
DOI : 10.1086/338833

S. Temmerman, K. Pethe, M. Parra, S. Alonso, C. Rouanet et al., Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin, Nature Medicine, vol.96, issue.9, pp.935-941, 2004.
DOI : 10.1128/IAI.69.9.5606-5611.2001

G. Guerrero and C. Locht, Recombinant HBHA boosting effect on BCGinduced immunity against mycobacterium tuberculosis infection, Clin Dev Immunol, p.730702, 2011.
DOI : 10.1155/2011/730702

URL : http://doi.org/10.1155/2011/730702

M. Parra, T. Pickett, G. Delogu, V. Dheenadhayalan, A. Debrie et al., The Mycobacterial Heparin-Binding Hemagglutinin Is a Protective Antigen in the Mouse Aerosol Challenge Model of Tuberculosis, Infection and Immunity, vol.72, issue.12, pp.726799-6805, 2004.
DOI : 10.1128/IAI.72.12.6799-6805.2004

R. Lambrecht, J. Carriere, and M. Collins, A model for analyzing growth kinetics of a slowly growing mycobacterium sp, Appl Environ Microbiol, vol.54, issue.4, pp.910-916, 1988.

J. Milstien and J. Gibson, Quality control of BCG vaccine by WHO: a review of factors that may influence vaccine effectiveness and safety. Bull World Health Organ, pp.93-108, 1990.

G. Dietrich, H. Mollenkopf, H. Weber, B. Knapp, K. Diehl et al., Cultivation of Mycobacterium bovis BCG in bioreactors, Journal of Biotechnology, vol.96, issue.3, pp.259-270, 2002.
DOI : 10.1016/S0168-1656(02)00046-9

J. Nyabenda, E. Bautens, M. Borremans, R. Verhofstadt, M. Weckx et al., The production of mycobacterial antigens by homogeneous culture in a fermentor, Journal of Biological Standardization, vol.16, issue.4, pp.259-267, 1988.
DOI : 10.1016/0092-1157(88)90013-3

F. Biet, A. De-melo-marques, M. Grayon, M. , X. Da-silveira et al., Mycobacterium smegmatis produces an HBHA homologue which is not involved in epithelial adherence, Microbes and Infection, vol.9, issue.2, pp.175-182, 2007.
DOI : 10.1016/j.micinf.2006.11.007

L. Lefrancois, C. Pujol, C. Bodier, A. Teixeira-gomez, H. Drobecq et al., Characterization of the mycobacterium avium subsp. Paratuberculosis laminin-binding/histonelike protein (Lbp/Hlp) which reacts with sera from patients with Crohn's disease. Microbes Infect, pp.585-594, 2011.
URL : https://hal.archives-ouvertes.fr/hal-01129782

F. Menozzi, J. Rouse, M. Alavi, M. Laude-sharp, J. Muller et al., Identification of a heparin-binding hemagglutinin present in mycobacteria, Journal of Experimental Medicine, vol.184, issue.3, pp.993-1001, 1996.
DOI : 10.1084/jem.184.3.993

P. Kanudia, M. Mittal, S. Kumaran, and P. Chakraborti, Amino-terminal extension present in the methionine aminopeptidase type 1c of Mycobacterium tuberculosis is indispensible for its activity, BMC Biochemistry, vol.12, issue.1, p.35, 2011.
DOI : 10.1016/0263-7855(96)00018-5

X. Zhang, S. Chen, Z. Hu, L. Zhang, and H. Wang, Expression and Characterization of Two Functional Methionine Aminopeptidases from Mycobacterium tuberculosis H37Rv, Current Microbiology, vol.3, issue.5, pp.520-525, 2009.
DOI : 10.1007/s00284-009-9470-3

C. Hwang, A. Shemorry, and A. Varshavsky, N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals, Science, vol.327, issue.5968, pp.973-977, 2010.
DOI : 10.1126/science.1183147

L. Okkels, E. Muller, M. Schmid, I. Rosenkrands, S. Kaufmann et al., CFP10 discriminates between nonacetylated and acetylated ESAT-6 ofMycobacterium tuberculosis by differential interaction, PROTEOMICS, vol.4, issue.10, pp.2954-2960, 2004.
DOI : 10.1002/pmic.200400906

U. Laemmli, Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4, Nature, vol.244, issue.5259, pp.680-685
DOI : 10.1038/227680a0

M. Bourin, J. Gautron, M. Berges, S. Attucci, L. Blay et al., Antimicrobial Potential of Egg Yolk Ovoinhibitor, a Multidomain Kazal-like Inhibitor of Chicken Egg, Journal of Agricultural and Food Chemistry, vol.59, issue.23, pp.5912368-12374, 2011.
DOI : 10.1021/jf203339t

URL : https://hal.archives-ouvertes.fr/hal-01129593

A. Keller, A. Nesvizhskii, E. Kolker, and R. Aebersold, Empirical Statistical Model To Estimate the Accuracy of Peptide Identifications Made by MS/MS and Database Search, Analytical Chemistry, vol.74, issue.20, pp.745383-5392, 2002.
DOI : 10.1021/ac025747h

A. Nesvizhskii, A. Keller, E. Kolker, and R. Aebersold, A Statistical Model for Identifying Proteins by Tandem Mass Spectrometry, Analytical Chemistry, vol.75, issue.17, pp.754646-4658, 2003.
DOI : 10.1021/ac0341261

S. Beausoleil, J. Villen, S. Gerber, J. Rush, and S. Gygi, A probability-based approach for high-throughput protein phosphorylation analysis and site localization, Nature Biotechnology, vol.5, issue.10, pp.1285-1292, 2006.
DOI : 10.1021/pr0499794