L. Guariguata, D. Whiting, and I. Hambleton, Global estimates of diabetes prevalence for 2013 and projections for 2035, Diabetes Research and Clinical Practice, vol.103, issue.2, pp.137-149, 2014.
DOI : 10.1016/j.diabres.2013.11.002

E. Barr, P. Zimmet, and T. Welborn, Risk of Cardiovascular and All-Cause Mortality in Individuals With Diabetes Mellitus, Impaired Fasting Glucose, and Impaired Glucose Tolerance: The Australian Diabetes, Obesity, and Lifestyle Study (AusDiab), Circulation, vol.116, issue.2, pp.151-157, 2007.
DOI : 10.1161/CIRCULATIONAHA.106.685628

J. Baynes and S. Thorpe, The role of oxidative stress in diabetic complications, Current Opinion in Endocrinology and Diabetes, vol.3, issue.4, pp.1-9, 1999.
DOI : 10.1097/00060793-199608000-00001

S. Zatalia and H. Sanusi, The role of antioxidants in the pathophysiology, complications, and management of diabetes mellitus, Acta Mad Indonses, vol.45, pp.141-147, 2013.

M. Hamberg, J. Svensson, and B. Samuelsson, Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides., Proceedings of the National Academy of Sciences, vol.72, issue.8, pp.2994-2998, 1975.
DOI : 10.1073/pnas.72.8.2994

E. Véricel, C. Januel, and M. Carreras, Diabetic Patients Without Vascular Complications Display Enhanced Basal Platelet Activation and Decreased Antioxidant Status, Diabetes, vol.53, issue.4, pp.1046-1051, 2004.
DOI : 10.2337/diabetes.53.4.1046

E. Feskens, S. Virtanen, and L. Rasanen, Dietary Factors Determining Diabetes and Impaired Glucose Tolerance: A 20-year follow-up of the Finnish and Dutch cohorts of the Seven Countries Study, Diabetes Care, vol.18, issue.8, pp.1104-1112, 1995.
DOI : 10.2337/diacare.18.8.1104

D. Caterina, R. Madonna, R. Bertolotto, and A. , n-3 Fatty Acids in the Treatment of Diabetic Patients: Biological rationale and clinical data, Diabetes Care, vol.30, issue.4, pp.1012-1026, 2007.
DOI : 10.2337/dc06-1332

L. Gao, J. Cao, and Q. Mao, Influence of omega-3 polyunsaturated fatty acid-supplementation on platelet aggregation in humans: A meta-analysis of randomized controlled trials, Atherosclerosis, vol.226, issue.2, pp.328-334, 2013.
DOI : 10.1016/j.atherosclerosis.2012.10.056

A. Erkkilä, N. Matthan, and D. Herrington, Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD, The Journal of Lipid Research, vol.47, issue.12, pp.2814-2819, 2006.
DOI : 10.1194/jlr.P600005-JLR200

F. Sacks, P. Stone, and C. Gibson, Controlled trial of fish oil for regression of human coronary atherosclerosis, Journal of the American College of Cardiology, vol.25, issue.7, pp.1492-1498, 1995.
DOI : 10.1016/0735-1097(95)00095-L

K. Yagi, Lipid peroxides and human diseases, Chemistry and Physics of Lipids, vol.45, issue.2-4, pp.337-351, 1987.
DOI : 10.1016/0009-3084(87)90071-5

E. Véricel, A. Polette, and S. Bacot, Pro- and antioxidant activities of docosahexaenoic acid on human blood platelets, Journal of Thrombosis and Haemostasis, vol.279, issue.3, pp.566-572, 2003.
DOI : 10.1046/j.1538-7836.2003.00076.x

N. Guillot, E. Caillet, and M. Laville, Increasing intakes of the long-chain ??-3 docosahexaenoic acid: effects on platelet functions and redox status in healthy men, The FASEB Journal, vol.23, issue.9, pp.2909-2916, 2009.
DOI : 10.1096/fj.09-133421

URL : https://hal.archives-ouvertes.fr/inserm-00387440

M. Lagarde, P. Bryon, and M. Guichardant, A simple and efficient method for platelet isolation from their plasma, Thrombosis Research, vol.17, issue.3-4, pp.581-588, 1980.
DOI : 10.1016/0049-3848(80)90098-5

G. Born, Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal, Nature, vol.14, issue.4832, pp.927-929, 1962.
DOI : 10.1016/0006-3002(61)90250-5

D. Boukhchache and M. Lagarde, Interactions between prostaglandin precursors during their oxygenation by human platelets, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol.713, issue.2, pp.386-392, 1982.
DOI : 10.1016/0005-2760(82)90257-0

M. Croset, E. Véricel, and M. Rigaud, Functions and tocopherol content of blood platelets from elderly people after low intake of purified eicosapentaenoic acid, Thrombosis Research, vol.57, issue.1, pp.1-12, 1990.
DOI : 10.1016/0049-3848(90)90190-N

J. Therasse and F. Lemonnier, Determination of plasma lipoperoxides by high-performance liquid chromatography, Journal of Chromatography B: Biomedical Sciences and Applications, vol.413, pp.237-241, 1987.
DOI : 10.1016/0378-4347(87)80232-3

D. Bowyer, W. Leat, and A. Howard, The determination of the fatty acid composition of serum lipids separated by thin-layer chromatography; and a comparison with column chromatography, Biochimica et Biophysica Acta, vol.70, pp.423-431, 1963.
DOI : 10.1016/0006-3002(63)90772-8

R. Woodman, T. Mori, and V. Burke, Effects of purified eicosapentaenoic acid and docosahexaenoic acid on platelet, fibrinolytic and vascular function in hypertensive type 2 diabetic patients, Atherosclerosis, vol.166, issue.1, pp.85-93, 2003.
DOI : 10.1016/S0021-9150(02)00307-6

P. Venkatakrishnan, S. Anuradha, and J. Bhattacharjee, Effects of low dose of omega-3 fatty acids on platelet functions and coagulation profile in Indian patients with type 2 diabetes mellitus with vascular complications : a prospective, preliminary study, J Indian Acad Clin Med, vol.8, pp.45-52, 2007.

E. Corey, C. Shih, and J. Cashman, Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis., Proceedings of the National Academy of Sciences, vol.80, issue.12, pp.3581-3584, 1983.
DOI : 10.1073/pnas.80.12.3581

F. Catella, D. Healy, and . Lawson, 11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation., Proceedings of the National Academy of Sciences, vol.83, issue.16, pp.5861-5865, 1986.
DOI : 10.1073/pnas.83.16.5861

G. Davì, F. Chiarelli, and F. Santilli, Enhanced Lipid Peroxidation and Platelet Activation in the Early Phase of Type 1 Diabetes Mellitus: Role of Interleukin-6 and Disease Duration, Circulation, vol.107, issue.25, pp.3199-3203, 2003.
DOI : 10.1161/01.CIR.0000074205.17807.D0

M. Kesavulu, B. Kameswararao, and A. Ch, Effect of omega-3 fatty acids on lipid peroxidation and antioxidant enzyme status in type 2 diabetic patients, Diabetes Metab, vol.28, pp.20-26, 2002.

F. Azizi-soleiman, S. Jazayeri, and S. Eghtesadi, Effects of pure eicosapentaenoic and docosahexaenoic acids on oxidative stress, inflammation and body fat mass in patients with type 2 diabetes, Int J Prev Med, vol.8, pp.922-928, 2013.

D. F. Praticò, F2-isoprostanes: sensitive and specific non-invasive indices of lipid peroxidation in vivo, Atherosclerosis, vol.147, issue.1, pp.1-10, 1999.
DOI : 10.1016/S0021-9150(99)00257-9

T. Mori, R. Woodman, and V. Burke, Effect of eicosapentaenoic acid and docosahexaenoic acid on oxidative stress and inflammatory markers in treated-hypertensive type 2 diabetic subjects, Free Radical Biology and Medicine, vol.35, issue.7, pp.772-781, 2003.
DOI : 10.1016/S0891-5849(03)00407-6

D. Mcdonald, O. Kane, F. Mcconville, and M. , Platelet Redox Balance in Diabetic Patients With Hypertension Improved by n-3 Fatty Acids, Diabetes Care, vol.36, issue.4, pp.998-1005, 2013.
DOI : 10.2337/dc12-0304

J. Nourooz-zadeh, A. Rahimi, and J. Tajaddini-sarmadi, Relationships between plasma measures of oxidative stress and metabolic control in NIDDM, Diabetologia, vol.40, issue.6, pp.647-653, 1997.
DOI : 10.1007/s001250050729

A. Pirillo and A. Catapano, Omega-3 polyunsaturated fatty acids in the treatment of atherogenic dyslipidemia, Atherosclerosis Supplements, vol.14, issue.2, pp.237-242, 2013.
DOI : 10.1016/S1567-5688(13)70004-7

C. Von-schacky and P. Weber, Metabolism and effects on platelet function of the purified eicosapentaenoic and docosahexaenoic acids in humans., Journal of Clinical Investigation, vol.76, issue.6, pp.2446-2450, 1985.
DOI : 10.1172/JCI112261

J. Conquer and B. Holub, Supplementation with an algae source of docosahexaenoic acid increases (n-3) fatty acid status and alters selected risk factors for heart disease in vegetarian subjects, J Nutr, vol.12, pp.3032-3039, 1996.

J. Conquer and B. Holub, Dietary docosahexaenoic acid as a source of eicosapentaenoic acid in vegetarians and omnivores, Lipids, vol.274, issue.3, pp.341-345, 1997.
DOI : 10.1007/s11745-997-0043-y

S. Shaikh, J. Kinnun, and X. Leng, How polyunsaturated fatty acids modify molecular organization in membranes: Insight from NMR studies of model systems, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1848, issue.1, pp.5-273600155, 2009.
DOI : 10.1016/j.bbamem.2014.04.020

D. Jump, D. Botolin, and Y. Wang, Fatty acid regulation of hepatic gene transcription, J Nutr, vol.135, pp.2503-2506, 2005.

P. Mukherjee, V. Marcheselli, and C. Serhan, From The Cover: Neuroprotectin D1: A docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress, Proceedings of the National Academy of Sciences, vol.101, issue.22, pp.8491-8496, 2004.
DOI : 10.1073/pnas.0402531101

P. Chen, E. Véricel, and M. Lagarde, Poxytrins, a class of oxygenated products from polyunsaturated fatty acids, potently inhibit blood platelet aggregation, The FASEB Journal, vol.25, issue.1, pp.382-388, 2011.
DOI : 10.1096/fj.10-161836

URL : https://hal.archives-ouvertes.fr/inserm-00517396

. Min, Platelet lipids were extracted and separated by TLC, and metabolites of [ 14 C] ARA were quantified by radio-chromatography. Basal formations of TxB 2 in unstimulated platelets (in grey) and of one major urinary metabolites of TxB 2 , 11- dehydro-TxB 2, were quantified by immunoassays. Plasma, platelet vitamin E (alphatocopherol) and platelet MDA were extracted and quantified after HPLC separation. Urinary isoprostanes were quantified by immunoassays. There were no significant differences between pre placebo and post placebo values. All values are means ± SEM