E. Nuesch, All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study, BMJ, vol.342, issue.mar08 2, p.1165, 2011.
DOI : 10.1136/bmj.d1165

G. Leardini, Direct and indirect costs of osteoarthritis of the knee, Clin. Exp. Rheumatol, vol.22, pp.699-706, 2004.

R. F. Loeser, Osteoarthritis: A disease of the joint as an organ, Arthritis & Rheumatism, vol.216, issue.6, pp.1697-1707, 2012.
DOI : 10.1111/j.1469-7580.2009.01186.x

M. B. Goldring and K. B. Marcu, Cartilage homeostasis in health and rheumatic diseases, Arthritis Research & Therapy, vol.11, issue.3, p.224, 2009.
DOI : 10.1186/ar2592

URL : https://arthritis-research.biomedcentral.com/track/pdf/10.1186/ar2592?site=arthritis-research.biomedcentral.com

A. R. Amin, COX-2, NO, and cartilage damage and repair, Current Rheumatology Reports, vol.11, issue.3, pp.447-453, 2000.
DOI : 10.4324/9780203303726_chapter_22

H. F. Hart, Quadriceps volumes are reduced in people with patellofemoral joint osteoarthritis, Osteoarthritis and Cartilage, vol.20, issue.8, pp.863-868, 2012.
DOI : 10.1016/j.joca.2012.04.009

URL : https://doi.org/10.1016/j.joca.2012.04.009

C. Chappard, Subchondral bone micro-architectural alterations in osteoarthritis: a synchrotron micro-computed tomography study, Osteoarthritis and Cartilage, vol.14, issue.3, pp.215-223, 2006.
DOI : 10.1016/j.joca.2005.09.008

URL : https://doi.org/10.1016/j.joca.2005.09.008

L. Pesesse, Osteochondral plate angiogenesis: A new treatment target in osteoarthritis, Joint Bone Spine, vol.78, issue.2, pp.144-149, 2011.
DOI : 10.1016/j.jbspin.2010.07.001

P. I. Mapp, Angiogenesis in two animal models of osteoarthritis, Osteoarthritis and Cartilage, vol.16, issue.1, pp.61-69, 2008.
DOI : 10.1016/j.joca.2007.05.017

H. Nakamura, Application of glucosamine on human disease???Osteoarthritis, Carbohydrate Polymers, vol.84, issue.2, pp.835-839, 2011.
DOI : 10.1016/j.carbpol.2010.08.078

J. Clouet, From osteoarthritis treatments to future regenerative therapies for cartilage, Drug Discovery Today, vol.14, issue.19-20, pp.913-925, 2009.
DOI : 10.1016/j.drudis.2009.07.012

D. T. Felson, Osteoarthritis: New Insights. Part 2: Treatment Approaches, Annals of Internal Medicine, vol.133, issue.9, pp.726-737, 2000.
DOI : 10.7326/0003-4819-133-9-200011070-00015

N. Akhtar and T. M. Haqqi, Current nutraceuticals in the management of osteoarthritis: a review, Therapeutic Advances in Musculoskeletal Disease, vol.3, issue.3, pp.181-207, 2012.
DOI : 10.1016/j.phymed.2009.09.007

S. H. Zeisel, HEALTH:Regulation of "Nutraceuticals", Science, vol.285, issue.5435, pp.1853-1855, 1999.
DOI : 10.1126/science.285.5435.1853

E. K. Kalra, Nutraceutical: definition and introduction Role of nutraceuticals in human health, AAPS PharmSci. J. Food Sci. Technol, vol.5, issue.49, pp.173-183, 2003.

Y. Henrotin, Nutraceuticals: do they represent a new era in the management of osteoarthritis? ??? a narrative review from the lessons taken with five products, Osteoarthritis and Cartilage, vol.19, issue.1, pp.1-21, 2011.
DOI : 10.1016/j.joca.2010.10.017

T. E. Mcalindon, Relation of Dietary Intake and Serum Levels of Vitamin D to Progression of Osteoarthritis of the Knee among Participants in the Framingham Study, Annals of Internal Medicine, vol.125, issue.5, pp.353-359, 1996.
DOI : 10.7326/0003-4819-125-5-199609010-00001

C. T. Vangsness and . Jr, A Review of Evidence-Based Medicine for Glucosamine and Chondroitin Sulfate Use in Knee Osteoarthritis, Arthroscopy: The Journal of Arthroscopic & Related Surgery, vol.25, issue.1, pp.86-94, 2009.
DOI : 10.1016/j.arthro.2008.07.020

M. H. Gregory, A Review of Translational Animal Models for Knee Osteoarthritis, Arthritis, vol.37, issue.1, supplement, p.764621, 2012.
DOI : 10.2460/ajvr.2002.63.276

C. B. Little and M. M. Smith, Animal Models of Osteoarthritis, Current Rheumatology Reviews, vol.4, issue.3, 2008.
DOI : 10.2174/157339708785133523

H. Aini, Procyanidin B3 Prevents Articular Cartilage Degeneration and Heterotopic Cartilage Formation in a Mouse Surgical Osteoarthritis Model, PLoS ONE, vol.40, issue.5, p.37728, 2012.
DOI : 10.1371/journal.pone.0037728.t001

URL : https://doi.org/10.1371/journal.pone.0037728

W. P. Chen, Anti-arthritic effects of chlorogenic acid in interleukin-1??-induced rabbit chondrocytes and a rabbit osteoarthritis model, International Immunopharmacology, vol.11, issue.1, pp.23-28, 2011.
DOI : 10.1016/j.intimp.2010.09.021

, Reviews POST SCREEN, vol.24

N. Elmali, Effect of resveratrol in experimental osteoarthritis in rabbits, Inflammation Research, vol.54, issue.4, pp.158-162, 2005.
DOI : 10.1007/s00011-004-1341-6

J. Wang, Effect of resveratrol on cartilage protection and apoptosis inhibition in experimental osteoarthritis of rabbit, Rheumatology International, vol.26, issue.9, pp.1541-1548, 2012.
DOI : 10.1002/1529-0131(200006)43:6<1290::AID-ANR11>3.0.CO;2-R

K. D. Ham, Effects of long-term estrogen replacement therapy on articular cartilage IGFBP-2, IGFBP-3, collagen and proteoglycan levels in ovariectomized cynomolgus monkeys, Osteoarthritis and Cartilage, vol.12, issue.2, pp.160-168, 2004.
DOI : 10.1016/j.joca.2003.08.002

E. C. Castillo, Effects of Vitamin D Supplementation during the Induction and Progression of Osteoarthritis in a Rat Model, Evidence-Based Complementary and Alternative Medicine, vol.17, issue.9, p.156563, 2012.
DOI : 10.1186/1476-9255-5-10

T. Kobayashi, Fursultiamine, a vitamin B1 derivative, enhances chondroprotective effects of glucosamine hydrochloride and chondroitin sulfate in rabbit experimental osteoarthritis, Inflammation Research, vol.54, issue.6, pp.249-255, 2005.
DOI : 10.1007/s00011-005-1351-z

C. Boileau, Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13 Modification of articular cartilage and subchondral bone pathology in an ovine meniscectomy model of osteoarthritis by avocado and soya unsaponifiables (ASU) Osteoarthritis Cartilage, Arthritis Res. Ther, vol.11, issue.8, pp.404-411, 2000.

X. Zhou, -Catenin Signalling Pathway and Alleviates Osteoarthritis: An In Vitro and In Vivo Study, Evidence-Based Complementary and Alternative Medicine, vol.4, issue.9, p.809579, 2013.
DOI : 10.1038/ncprheum0904

G. Tiraloche, Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis, Arthritis & Rheumatism, vol.50, issue.4, pp.1118-1128, 2005.
DOI : 10.4049/jimmunol.166.8.5155

W. Hongbin, Carboxymethylated chitin reduces MMP-1 expression in rabbit ACLT osteoarthritic cartilage, Annals of the Rheumatic Diseases, vol.63, issue.4, pp.369-372, 2004.
DOI : 10.1136/ard.2002.001461

L. Lippiello, In Vivo Chondroprotection and Metabolic Synergy of Glucosamine and Chondroitin Sulfate, Clinical Orthopaedics and Related Research, vol.381, pp.229-240, 2000.
DOI : 10.1097/00003086-200012000-00027

C. Boileau, Oral treatment with a Brachystemma calycinum D don plant extract reduces disease symptoms and the development of cartilage lesions in experimental dog osteoarthritis: inhibition of protease-activated receptor 2, Annals of the Rheumatic Diseases, vol.69, issue.6, pp.1179-1184, 2009.
DOI : 10.1136/ard.2009.110965

P. F. Hu, Protective Effects of Berberine in an Experimental Rat Osteoarthritis Model, Phytotherapy Research, vol.26, issue.6, pp.878-885, 2011.
DOI : 10.1002/jor.20683

W. P. Chen, Morin inhibits interleukin-1??-induced nitric oxide and prostaglandin E2 production in human chondrocytes, International Immunopharmacology, vol.12, issue.2, pp.447-452, 2012.
DOI : 10.1016/j.intimp.2011.12.024

M. Hadipour-jahromy and R. Mozaffari-kermani, Chondroprotective effects of pomegranate juice on monoiodoacetate-induced osteoarthritis of the knee joint of mice, Phytotherapy Research, vol.66, pp.182-185, 2010.
DOI : 10.1080/01926230390241800

Y. J. Woo, Grape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis, Experimental and Molecular Medicine, vol.31, issue.Suppl 3, pp.561-570, 2011.
DOI : 10.1248/bpb.31.240

URL : https://www.nature.com/articles/emm201164.pdf

Z. Ashkavand, Silymarin potentiates the anti-inflammatory effects of Celecoxib on chemically induced osteoarthritis in rats, Phytomedicine, vol.19, issue.13, p.1200, 2012.
DOI : 10.1016/j.phymed.2012.07.008

K. M. Kalff, Pre-treatment with capsaicin in a rat osteoarthritis model reduces the symptoms of pain and bone damage induced by monosodium iodoacetate, European Journal of Pharmacology, vol.641, issue.2-3, pp.108-113, 2010.
DOI : 10.1016/j.ejphar.2010.05.022

M. Moreau, Clinical evaluation of a powder of quality elk velvet antler for the treatment of osteoarthrosis in dogs, Can. Vet. J, vol.45, pp.133-139, 2004.

M. Moreau, Effects of feeding a high omega-3 fatty acids diet in dogs with naturally occurring osteoarthritis, Journal of Animal Physiology and Animal Nutrition, vol.164, pp.830-837, 2004.
DOI : 10.1136/vr.164.14.418

R. J. Corbee, The effect of dietary long-chain omega-3 fatty acid supplementation on owner???s perception of behaviour and locomotion in cats with naturally occurring osteoarthritis, Journal of Animal Physiology and Animal Nutrition, vol.39, issue.Suppl. 1, pp.846-853, 2012.
DOI : 10.1016/j.jbiomech.2005.10.006

S. Fujita, Combined microwave irradiation and intraarticular glutamine administration-induced HSP70 expression therapy prevents cartilage degradation in a rat osteoarthritis model, Journal of Orthopaedic Research, vol.52, issue.Suppl, pp.401-407, 2011.
DOI : 10.1021/jm801445c

URL : http://onlinelibrary.wiley.com/doi/10.1002/jor.21535/pdf

W. P. Chen, study, Experimental Biology and Medicine, vol.28, issue.4, pp.380-386, 2012.
DOI : 10.1016/j.bcp.2005.03.008

URL : https://hal.archives-ouvertes.fr/hal-00738047

T. Phitak, Chondroprotective and anti-inflammatory effects of sesamin, Phytochemistry, vol.80, pp.77-88, 2012.
DOI : 10.1016/j.phytochem.2012.05.016

D. Uebelhart, Protective effect of exogenous chondroitin 4,6-sulfate in the acute degradation of articular cartilage in the rabbit, Osteoarthritis and Cartilage, vol.6, pp.6-13, 1998.
DOI : 10.1016/S1063-4584(98)80005-8

J. Ezaki, Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model, Journal of Bone and Mineral Metabolism, vol.45, issue.528403, pp.16-25, 2013.
DOI : 10.1016/j.fct.2006.12.003

B. Kurz, Dietary vitamins and selenium diminish the development of mechanically induced osteoarthritis and increase the expression of antioxidative enzymes in the knee joint of STR/1N mice, Osteoarthritis and Cartilage, vol.10, issue.2, pp.119-126, 2002.
DOI : 10.1053/joca.2001.0489

L. Knott, Regulation of osteoarthritis by omega-3 (n-3) polyunsaturated fatty acids in a naturally occurring model of disease, Osteoarthritis and Cartilage, vol.19, issue.9, pp.1150-1157, 2011.
DOI : 10.1016/j.joca.2011.06.005

M. J. Rein, Bioavailability of bioactive food compounds: a challenging journey to bioefficacy, British Journal of Clinical Pharmacology, vol.35, issue.8 Suppl., pp.588-602, 2013.
DOI : 10.1002/j.1552-4604.1995.tb04034.x

C. Manach, Polyphenols: food sources and bioavailability, The American Journal of Clinical Nutrition, vol.18, issue.5, pp.727-747, 2004.
DOI : 10.2165/00002018-199818040-00002

URL : https://academic.oup.com/ajcn/article-pdf/79/5/727/23713284/znu00504000727.pdf

H. L. Yang, Antioxidant and Anti-Inflammatory Potential of Hesperetin Metabolites Obtained from Hesperetin-Administered Rat Serum: An Ex Vivo Approach, Journal of Agricultural and Food Chemistry, vol.60, issue.1, pp.522-532, 2011.
DOI : 10.1021/jf2040675

P. A. Kroon, How should we assess the effects of exposure to dietary polyphenols in vitro?, The American Journal of Clinical Nutrition, vol.372, issue.1, pp.15-21, 2004.
DOI : 10.1006/abbi.1999.1516

C. L. Shen, Dietary polyphenols and mechanisms of osteoarthritis, The Journal of Nutritional Biochemistry, vol.23, issue.11, pp.1367-1377, 2012.
DOI : 10.1016/j.jnutbio.2012.04.001

K. P. Pritzker, Osteoarthritis cartilage histopathology: grading and staging, Osteoarthritis and Cartilage, vol.14, issue.1, pp.13-29, 2006.
DOI : 10.1016/j.joca.2005.07.014

A. Villalvilla, Lipid Transport and Metabolism in Healthy and Osteoarthritic Cartilage, International Journal of Molecular Sciences, vol.64, issue.10, pp.20793-20808, 2013.
DOI : 10.1002/art.34323

URL : http://www.mdpi.com/1422-0067/14/10/20793/pdf

C. R. Scanzello, Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?, Current Opinion in Rheumatology, vol.20, issue.5, pp.565-572, 2008.
DOI : 10.1097/BOR.0b013e32830aba34

P. C. Calder, Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?, British Journal of Clinical Pharmacology, vol.8, issue.2, pp.645-662, 2013.
DOI : 10.2903/j.efsa.2010.1461

URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04374.x/pdf

F. Wauquier, The Free Fatty Acid Receptor G Protein-coupled Receptor 40 (GPR40) Protects from Bone Loss through Inhibition of Osteoclast Differentiation, Journal of Biological Chemistry, vol.83, issue.9, pp.6542-6551, 2013.
DOI : 10.1194/jlr.M800626-JLR200

C. Jomphe, Chondroitin sulfate inhibits the nuclear translocation of nuclear factor-kappaB in interleukin-1beta-stimulated chondrocytes, Basic Clin. Pharmacol. Toxicol, vol.102, pp.59-65, 2008.

T. Matsuzaki, Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice, Annals of the Rheumatic Diseases, vol.54, issue.7, 2013.
DOI : 10.1002/hep.24471

, Ann. Rheum. Dis, vol.73, pp.1397-1404

B. P. Hubbard, Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators, Science, vol.394, issue.1, pp.1216-1219, 2013.
DOI : 10.1016/j.ab.2009.07.019