Mitosis and apoptosis: how is the balance set?, Curr. Opin. Cell Biol, vol.25, pp.780-785, 2013. ,
Cancer cells display profound intra-and interline variation following prolonged exposure to anti-mitotic drugs, Cancer Cell, vol.14, pp.111-122, 2008. ,
Regulation of cancer cell survival by BCL2 family members upon prolonged mitotic arrest: opportunities for anticancer therapy, Anticancer Res, vol.32, pp.4225-4233, 2012. ,
Decoding and unlocking the BCL-2 dependency of cancer cells, Nat. Rev. Cancer, vol.13, pp.455-465, 2013. ,
Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy, Cell, vol.160, pp.977-989, 2015. ,
Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells, Cell Death Differ, vol.17, pp.1624-1635, 2010. ,
Bcl-xL controls a switch between cell death modes during mitotic arrest, Cell Death Dis, vol.5, p.1291, 2014. ,
URL : https://hal.archives-ouvertes.fr/inserm-02446956
Phosphorylation of the pro-apoptotic BH3-only protein bid primes mitochondria for apoptosis during mitotic arrest, Cell Rep, vol.7, pp.661-671, 2014. ,
Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization, Proc. Natl Acad. Sci. USA, vol.107, pp.12634-12639, 2010. ,
The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrest, Nat. Commun, vol.6, pp.6891-6904, 2015. ,
Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy, Science, vol.334, pp.1129-1133, 2011. ,
A BH3 mimetic for killing cancer cells, Cell, vol.165, p.1560, 2016. ,
Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737, Proc. Natl Acad. Sci. USA, vol.109, pp.2766-2771, 2012. ,
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy, Sci. Transl. Med, vol.7, pp.279-319, 2015. ,
Exploiting MCL1 dependency with combination MEK + MCL1 inhibitors leads to induction of apoptosis and tumor regression in KRAS-mutant non-small cell, Lung Cancer Cancer Discov, vol.8, pp.1598-1613, 2018. ,
cGAS surveillance of micronuclei links genome instability to innate immunity, Nature, vol.548, pp.461-465, 2017. ,
Mitotic progression following DNA damage enables pattern recognition within micronuclei, Nature, vol.548, pp.466-470, 2017. ,
Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA, Cell, vol.159, pp.1563-1577, 2014. ,
Apoptotic caspases suppress mtDNA-induced STINGmediated type I IFN production, Cell, vol.159, pp.1549-1562, 2014. ,
Notch inhibition triggers cell death in breast cancer cells and breast tumors through Noxa activation, Breast Cancer Res, vol.14, p.96, 2012. ,
Design of amidobenzimidazole STING receptor agonists with systemic activity, Nature, vol.564, pp.439-443, 2018. ,
Complex regulation pattern of IRF3 activation revealed by a novel dimerization reporter system, J. Immunol, vol.196, pp.4322-4430, 2016. ,
Catastrophic nuclear envelope collapse in cancer cell micronuclei, Cell, vol.154, pp.47-60, 2013. ,
STING signaling in tumorigenesis and cancer therapy: a friend or foe?, Cancer Lett, vol.402, pp.203-212, 2017. ,
STING: infection, inflammation and cancer, Nat. Rev. Immunol, vol.15, pp.760-770, 2015. ,
DNA-containing exosomes derived from cancer cells treated with topotecan activate a STING-dependent pathway and reinforce antitumor immunity, J. Immunol, vol.198, pp.1649-1659, 2017. ,
Deregulation of STING signaling in colorectal carcinoma constrains DNA damage responses and correlates with tumorigenesis, Cell Rep, vol.14, pp.282-297, 2016. ,
PARP inhibitor efficacy depends on CD8+ T-cell recruitment via Intratumoral STING pathway activation in BRCA-deficient models of triple-negative breast cancer, Cancer Discov, vol.9, pp.722-737, 2019. ,
Activation of IFN/STAT1 signalling predicts response to chemotherapy in oestrogen receptor-negative breast cancer, Br. J. Cancer, vol.114, pp.177-187, 2016. ,
Alterations in tumor necrosis factor signaling pathways are associated with cytotoxicity and resistance to taxanes: a study in isogenic resistant tumor cells, Breast Cancer Res, vol.14, p.2, 2012. ,
Plasticity of Type I interferonmediated responses in cancer therapy: from anti-tumor immunity to resistance, Front. Oncol, vol.8, p.322, 2018. ,
Tumour necrosis factor and cancer, Nat. Rev. Cancer, vol.9, pp.361-371, 2009. ,
Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy, Nat. Med, vol.20, pp.1301-1309, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-02047408
Homogeneous expansion of human T-regulatory cells via tumor necrosis factor receptor 2, Sci. Rep, vol.3, pp.3153-3164, 2013. ,
Intracellular nucleic acid sensing triggers necroptosis through synergistic type I IFN and TNF signaling, J. Immunol, vol.200, pp.2748-2756, 2018. ,
Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection, J. Biol. Chem, vol.280, pp.15561-15568, 2005. ,
Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency, Cancer Cell, vol.21, pp.547-562, 2012. ,
Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity, Nat. Commun, vol.9, p.3513, 2018. ,
Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets, Cancer Discov, vol.4, pp.232-245, 2014. ,
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy, Nat. Commun, vol.9, p.3267, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01879955
CD95/Fas increases stemness in cancer cells by inducing a STAT1-dependent type I interferon response, Cell Rep, vol.18, pp.2373-2386, 2017. ,
An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer, Proc. Natl Acad. Sci. USA, vol.105, pp.18490-18495, 2008. ,
IFN?-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage, EMBO J, vol.32, pp.2751-2763, 2013. ,
IFN-? directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity, J. Immunol, vol.186, pp.2772-2779, 2011. ,
TNF? blockade overcomes resistance to anti-PD-1 in experimental melanoma, Nat. Commun, vol.8, p.2256, 2017. ,
ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL, Cancer Res, vol.71, pp.4518-4526, 2011. ,
ABT-263) reduces Bcl-x(L)-mediated chemoresistance in ovarian cancer models, Mol. Cancer Ther, vol.11, pp.1026-1035, 2012. ,
Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells, Oncotarget, vol.8, pp.45088-45104, 2017. ,
A phase I safety and pharmacokinetic study of ABT-263 in combination with carboplatin/paclitaxel in the treatment of patients with solid tumors, Invest. N. Drugs, vol.32, pp.976-984, 2014. ,
Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors, J. Clin. Oncol, vol.29, pp.909-916, 2011. ,
Why do BCL-2 inhibitors work and where should we use them in the clinic?, Cell Death Differ, vol.25, pp.56-64, 2018. ,
Genome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptation, EMBO J, vol.33, pp.1960-1976, 2014. ,
Signalling strength determines pro-apoptotic functions of STING, Nat. Commun, vol.8, p.427, 2017. ,
RIPK1 and NF-?B signaling in dying cells determines crosspriming of CD8 + T cells, Science, vol.350, pp.328-334, 2015. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01380732
Mitochondrial permeabilization engages NF-?Bdependent anti-tumour activity under caspase deficiency, Nat. Cell Biol, vol.19, pp.1116-1129, 2017. ,
Mitochondrial DNA stress primes the antiviral innate immune response, Nature, vol.520, pp.553-557, 2015. ,
Dying cells actively regulate adaptive immune responses, Nat. Rev. Immunol, vol.17, pp.262-275, 2017. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01491773
Functionally identifiable apoptosis-insensitive subpopulations determine chemoresistance in acute myeloid leukemia, J. Clin. Invest, vol.126, pp.3827-3836, 2016. ,
Chromosomal instability drives metastasis through a cytosolic DNA response, Nature, vol.553, pp.467-472, 2018. ,
Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis, J. Cell Biol, vol.179, pp.255-267, 2007. ,
Improved vectors and genome-wide libraries for CRISPR screening, Nat. Methods, vol.11, pp.783-784, 2014. ,
A living captures disease biobank of breast cancer organoids heterogeneity, Cell, vol.172, pp.373-386, 2018. ,
Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes, Nat. Med, vol.17, pp.1514-1520, 2011. ,
Gene-expression molecular subtyping of triple-negative breast cancer tumours: importance of immune response, Breast Cancer Res, vol.17, p.43, 2015. ,
The cytoplasmic DNA sensor cGAS promotes mitotic cell death, 2017. ,
Parallel derivation of isogenic human primed and naive induced pluripotent stem cells, Nat. Commun, vol.9, p.360, 2018. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01758726
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update, Nucleic Acids Res, vol.44, pp.90-97, 2016. ,