Metabolic pathways promoting cancer cell survival and growth, Nat. Cell Biol, vol.17, pp.351-359, 2015. ,
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis, Proc. Natl. Acad. Sci, vol.104, 2007. ,
Hallmarks of cancer: The next generation, Cell, vol.144, pp.646-674, 2011. ,
Understanding the intersections between metabolism and cancer biology, vol.168, pp.657-669, 2017. ,
On respiratory impairment in cancer cells, Science, vol.124, pp.269-270, 1956. ,
On the origin of cancer cells, Science, vol.123, pp.309-314, 1956. ,
Cancer cell metabolism: Warburg and beyond, Cell, vol.134, pp.703-707, 2008. ,
The warburg effect: How does it benefit cancer cells?, Trends Biochem. Sci, vol.41, pp.211-218, 2016. ,
, Int. J. Mol. Sci, vol.19, p.3325, 2018.
Surviving the harsh tumor microenvironment, Trends Cell Biol, vol.24, pp.472-478, 2014. ,
Hooked on fat: The role of lipid synthesis in cancer metabolism and tumour development, Dis. Model Mech, vol.6, pp.1353-1363, 2013. ,
Lipid metabolism reprogramming and its potential targets in cancer, Cancer Commun. (Lond, vol.38, 2018. ,
The multifaceted roles of fatty acid synthesis in cancer, Nat. Rev. Cancer, vol.16, pp.732-749, 2016. ,
Lipid landscapes and pipelines in membrane homeostasis, Nature, vol.510, pp.48-57, 2014. ,
Membrane lipids: Where they are and how they behave, Nat. Rev. Mol. Cell Biol, vol.9, pp.112-124, 2008. ,
Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells, J. Biol. Chem, vol.282, pp.26122-26131, 2007. ,
Nutrient-sensing mechanisms and pathways, Nature, vol.517, pp.302-310, 2015. ,
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis, Nat. Rev. Cancer, vol.7, pp.763-777, 2007. ,
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate, Nature, vol.462, pp.739-744, 2009. ,
Cancer genome sequencing: A review, Hum. Mol. Genet, vol.18, pp.163-168, 2009. ,
An integrated genomic analysis of human glioblastoma multiforme, Science, vol.321, pp.1807-1812, 2008. ,
IDH1 and IDH2 mutations in gliomas, N. Engl. J. Med, vol.360, pp.765-773, 2009. ,
IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A cancer and leukemia group b study, J. Clin. Oncol, vol.28, pp.2348-2355, 2010. ,
IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication, J. Clin. Oncol, vol.28, pp.3636-3643, 2010. ,
TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics, Blood, vol.118, pp.3803-3810, 2011. ,
Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: A study by the acute leukemia french association group, J. Clin. Oncol, vol.28, pp.3717-3723, 2010. ,
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations, J. Exp. Med, vol.207, pp.339-344, 2010. ,
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate, Cancer Cell, vol.17, pp.225-234, 2010. ,
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases, Cancer Cell, vol.19, 2011. ,
IDH mutation, competitive inhibition of FTO, and RNA methylation, Cancer Cell, vol.31, pp.619-620, 2017. ,
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation, Cancer Cell, vol.18, pp.553-567, 2010. ,
Predicting IDH mutation status in grade II gliomas using amide proton transfer-weighted (APTW) MRI, Magn. Reson. Med, vol.78, pp.1100-1109, 2017. ,
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases, EMBO Rep, vol.12, pp.463-469, 2011. ,
Expanding the reach of cancer metabolomics, Cancer Prev. Res. (Phila.), vol.5, pp.1337-1340, 2012. ,
Genetically-defined metabolic reprogramming in cancer, Trends Endocrinol. Metab, vol.23, pp.552-559, 2012. ,
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of alpha-ketoglutarate to citrate to support cell growth and viability, Proc. Natl. Acad. Sci, vol.108, 2011. ,
MS-based lipidomics of human blood plasma: A community-initiated position paper to develop accepted guidelines, J. Lipid Res, vol.59, 2001. ,
Metabolism dysregulation induces a specific lipid signature of nonalcoholic steatohepatitis in patients ,
A rapid and simple method for the esterification of fatty acids and steroid carboxylic acids prior to gas-liquid chromatography, Clin. Chim. Acta, vol.111, pp.91-98, 1981. ,
Pre-beta HDL: Structure and metabolism, Biochim. Biophys. Acta, vol.1300, pp.73-85, 1996. ,
Cancer cells differentially activate and thrive on de novo lipid synthesis pathways in a low-lipid environment, PLoS ONE, vol.9, 2014. ,
Hypoxic and ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids, Proc. Natl. Acad. Sci, vol.110, pp.8882-8887, 2013. ,
PHD3 loss in cancer enables metabolic reliance on fatty acid oxidation via deactivation of ACC2, Mol. Cell, vol.63, pp.1006-1020, 2016. ,
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha, Science, vol.324, pp.261-265, 2009. ,
Chemotherapy-resistant human acute myeloid leukemia cells are not enriched for leukemic stem cells but require oxidative metabolism, vol.7, pp.716-735, 2017. ,
URL : https://hal.archives-ouvertes.fr/inserm-02465205
Activation of p53 signaling by MI-63 induces apoptosis in acute myeloid leukemia cells, Leuk. Lymphoma, vol.51, pp.911-919, 2010. ,
A rapid method of total lipid extraction and purification, Can. J. Biochem. Physiol, vol.37, pp.911-917, 1959. ,
Urinary lysophopholipids are increased in diabetic patients with nephropathy, J. Diabetes Complicat, vol.31, pp.1103-1108, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01941536
Metabolic reprogramming in mutant IDH1 glioma cells, PLoS ONE, vol.10, 2015. ,
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome, Proc. Natl. Acad. Sci, vol.108, pp.3270-3275, 2011. ,
Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner, Cancer Metab, vol.6, issue.3, 2018. ,
Lipid metabolic reprogramming in cancer cells ,
Acid ceramidase deficiency in mice results in a broad range of central nervous system abnormalities, Am. J. Pathol, vol.187, pp.864-883, 2017. ,
Lipid rafts as a membrane-organizing principle, Science, vol.327, pp.46-50, 2010. ,
Lipid rafts as major platforms for signaling regulation in cancer, Adv. Biol. Regul, vol.57, pp.130-146, 2015. ,
Re-configuration of sphingolipid metabolism by oncogenic transformation, Biomolecules, vol.4, pp.315-353, 2014. ,
Tracing the fate of dietary fatty acids: Metabolic studies of postprandial lipaemia in human subjects, Proc. Nutr. Soc, vol.70, pp.342-350, 2011. ,
Rapid measurement of plasma free fatty acid concentration and isotopic enrichment using lc/ms, J. Lipid Res, vol.51, pp.2761-2765, 2010. ,
A roadmap for interpreting (13)c metabolite labeling patterns from cells, Curr. Opin. Biotechnol, vol.34, pp.189-201, 2015. ,
An optimized method for measuring fatty acids and cholesterol in stable isotope-labeled cells, J. Lipid Res, vol.58, pp.460-468, 2017. ,
High fat feeding induces hepatic fatty acid elongation in mice, PLoS ONE, vol.4, p.6066, 2009. ,
Isocor: Correcting ms data in isotope labeling experiments, Bioinformatics, vol.28, pp.1294-1296, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-01268343
Durable remissions with ivosidenib in IDH1-mutated relapsed or refractory AML, N. Engl. J. Med, vol.378, pp.2386-2398, 2018. ,
Discovery of ag-120 (ivosidenib): A first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers, ACS Med. Chem. Lett, vol.9, pp.300-305, 2018. ,
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells, Science, vol.340, pp.626-630, 2013. ,
Sterol regulatory element binding protein regulates the expression and metabolic functions of wild-type and oncogenic IDH1, Mol. Cell Biol, vol.36, pp.2384-2395, 2016. ,
Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia, J. Exp. Med, vol.213, pp.483-497, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01886383