Clostridium difficile colitis: pathogenesis and host defence, Nat. Rev. Microbiol, vol.14, pp.609-620, 2016. ,
DOI : 10.1038/nrmicro.2016.108
URL : http://europepmc.org/articles/pmc5109054?pdf=render
The promise and peril of transcriptional profiling in biofilm communities, Curr. Opin. Microbiol, vol.10, pp.292-296, 2007. ,
Various functions of selenols and thiols in anaerobic gram-positive, amino acids-utilizing bacteria, Biofactors, vol.10, pp.263-270, 1999. ,
Global transcriptional control by glucose and carbon regulator CcpA in Clostridium difficile, Nucleic Acids Res, vol.40, pp.10701-10718, 2012. ,
DOI : 10.1093/nar/gks864
URL : https://hal.archives-ouvertes.fr/pasteur-01370790
Global impact of mature biofilm lifestyle on Escherichia coli K-12 gene expression, Mol. Microbiol, vol.51, pp.659-674, 2004. ,
DOI : 10.1046/j.1365-2958.2003.03865.x
URL : https://hal.archives-ouvertes.fr/pasteur-02080937
c-di-GMP turnover in Clostridium difficile is controlled by a plethora of diguanylate cyclases and phosphodiesterases, PLoS Genet, vol.7, p.1002039, 2011. ,
Cyclic di-GMP riboswitch-regulated type IV pili contribute to aggregation of Clostridium difficile, J. Bacteriol, vol.197, pp.819-832, 2015. ,
Integration of metabolism and virulence in Clostridium difficile, Res. Microbiol, vol.166, pp.375-383, 2015. ,
DOI : 10.1016/j.resmic.2014.10.002
URL : http://europepmc.org/articles/pmc4398617?pdf=render
Proline-dependent regulation of Clostridium difficile stickland metabolism, J. Bacteriol, vol.195, pp.844-854, 2013. ,
DOI : 10.1128/jb.01492-12
URL : https://jb.asm.org/content/195/4/844.full.pdf
The biofilm architecture of sixty opportunistic pathogens deciphered using a high throughput CLSM method, J. Microbiol. Methods, vol.82, pp.64-70, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-01204254
Infection of hamsters with the UK Clostridium difficile ribotype 027 outbreak strain R20291, J. Med. Microbiol, vol.60, pp.1174-1180, 2011. ,
Identification of a novel zinc metalloprotease through a global analysis of Clostridium difficile extracellular proteins, PLoS One, vol.8, 2013. ,
Biofilm formation by Bacillus subtilis: new insights into regulatory strategies and assembly mechanisms, Mol. Microbiol, vol.93, pp.587-598, 2014. ,
DOI : 10.1111/mmi.12697
URL : https://onlinelibrary.wiley.com/doi/pdf/10.1111/mmi.12697
Gas chromatographic-mass spectral studies after methylation of metabolites produced by some anaerobic bacteria in spent media, J. Chromatogr, vol.493, pp.257-273, 1989. ,
A Clostridium difficile cell wall glycopolymer locus influences bacterial shape. Polysaccharide production and virulence, PLoS Pathog, vol.12, p.1005946, 2016. ,
DOI : 10.1371/journal.ppat.1005946
URL : https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005946&type=printable
What's a SNP between friends: the influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives, Virulence, vol.8, pp.767-781, 2017. ,
Development and validation of a chemostat gut model to study both planktonic and biofilm modes of growth of Clostridium difficile and human microbiota, PLoS One, vol.9, p.88396, 2014. ,
Multiple factors modulate biofilm formation by the anaerobic pathogen Clostridium difficile, J. Bacteriol, vol.195, pp.545-555, 2013. ,
Biofilm formation by Clostridium difficile, Gut Microbes, vol.4, pp.397-402, 2013. ,
Characterisation of Clostridium difficile biofilm formation, a role for Spo0A, PLoS One, vol.7, p.50527, 2012. ,
High-throughput analysis of gene essentiality and sporulation in Clostridium difficile, vol.6, p.2383, 2015. ,
Acd, a peptidoglycan hydrolase of Clostridium difficile with N-acetylglucosaminidase activity, Microbiology, vol.151, pp.2343-2351, 2005. ,
Integration of metabolism and virulence by Clostridium difficile Cody, J. Bacteriol, vol.192, pp.5350-5362, 2010. ,
Control of Clostridium difficile physiopathology in response to cysteine availability, Infect. Immun, vol.84, pp.2389-2405, 2016. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01370880
Conserved oligopeptide permeases modulate sporulation initiation in Clostridium difficile, Infect. Immun, vol.82, pp.4276-4291, 2014. ,
DOI : 10.1128/iai.02323-14
URL : https://iai.asm.org/content/82/10/4276.full.pdf
Volatile acid production from threonine, valine, leucine and isoleucine by clostridia, Arch. Microbiol, vol.117, pp.165-172, 1978. ,
DOI : 10.1007/bf00402304
Clostridium difficile has two parallel and essential Sec secretion systems, J. Biol. Chem, vol.286, pp.27483-27493, 2011. ,
DOI : 10.1074/jbc.m111.263889
URL : http://www.jbc.org/content/286/31/27483.full.pdf
Gut microbiota-produced succinate promotes C. difficile infection after antibiotic treatment or motility disturbance, Cell Host Microbe, vol.16, pp.770-777, 2014. ,
DOI : 10.1016/j.chom.2014.11.003
URL : https://doi.org/10.1016/j.chom.2014.11.003
Molecular characterization of host-specific biofilm formation in a vertebrate gut symbiont, PLoS Genet, vol.9, p.1004057, 2013. ,
Clostridium difficile cell-surface polysaccharides composed of pentaglycosyl and hexaglycosyl phosphate repeating units, Carbohydr. Res, vol.343, pp.703-710, 2008. ,
DOI : 10.1016/j.carres.2008.01.002
Natural conjugative plasmids induce bacterial biofilm development, Nature, vol.412, pp.442-445, 2001. ,
DOI : 10.1038/35086581
Pleiotropic roles of Clostridium difficile sin locus, PLoS Pathog, vol.14, p.1006940, 2018. ,
DOI : 10.1371/journal.ppat.1006940
URL : https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006940&type=printable
Key role of teichoic acid net charge in Staphylococcus aureus colonization of artificial surfaces, Infect. Immun, vol.69, pp.3423-3426, 2001. ,
Evolving concepts in biofilm infections, Cell. Microbiol, vol.11, 2009. ,
Clostridium difficile secreted Pro-Pro endopeptidase PPEP-1 (ZMP1/CD2830) modulates adhesion through cleavage of the collagen binding protein CD2831, FEBS Lett, vol.589, pp.3952-3958, 2015. ,
A novel secreted metalloprotease (CD2830) from Clostridium difficile cleaves specific proline sequences in LPXTG cell surface proteins, Mol. Cell. Proteomics, vol.13, pp.1231-1244, 2014. ,
Giving structure to the biofilm matrix: an overview of individual strategies and emerging common themes, FEMS Microbiol. Rev, vol.39, pp.649-669, 2015. ,
Analysis of Clostridium difficile biofilms: imaging and antimicrobial treatment, J. Antimicrob. Chemother, vol.73, pp.102-108, 2017. ,
Virulence factors of Clostridium difficile and their role during infection, Anaerobe, vol.37, pp.13-24, 2016. ,
Adaptive strategies and pathogenesis of Clostridium difficile from in vivo transcriptomics, Infect. Immun, vol.81, pp.3757-3769, 2013. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01370786
Induction of toxins in Clostridium difficile is associated with dramatic changes of its metabolism, Microbiology, vol.154, pp.3430-3436, 2008. ,
, , 2000.
, butyric acid, and other short-chain fatty acids are coordinately expressed and down-regulated by cysteine in Clostridium difficile, Infect. Immun, vol.68, pp.5881-5888
Clostridium difficile is an autotrophic bacterial pathogen, PLoS One, vol.8, p.62157, 2013. ,
Lipoprotein CD0873 is a novel adhesin of Clostridium difficile, J. Infect. Dis, vol.210, pp.274-284, 2014. ,
Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice, PLoS Pathog, vol.8, p.1002995, 2012. ,
Lessons from DNA microarray analysis: the gene expression profile of biofilms, Curr. Opin. Microbiol, vol.8, pp.222-227, 2005. ,
Clostridium difficile Infection, N. Engl. J. Med, vol.373, pp.287-288, 2015. ,
Analysis of relative gene expression data using real-time quantitative PCR and the 2 ?CT method, Methods, vol.25, pp.402-408, 2001. ,
Involvement of an inducible fructose phosphotransferase operon in Streptococcus gordonii biofilm formation, J. Bacteriol, vol.185, pp.6241-6254, 2003. ,
Type IV pili promote early biofilm formation by Clostridium difficile, Pathog. Dis, vol.74, p.61, 2016. ,
The regulatory networks that control Clostridium difficile toxin synthesis, Toxins, vol.8, p.153, 2016. ,
The efficacy of thuricin CD, tigecycline, vancomycin, teicoplanin, rifampicin and nitazoxanide, independently and in paired combinations against Clostridium difficile biofilms and planktonic cells, Gut Pathog, vol.8, p.20, 2016. ,
The dlt operon confers resistance to cationic antimicrobial peptides in Clostridium difficile, Microbiology, vol.157, pp.1457-1465, 2011. ,
Type IV pili in Gram-positive bacteria. Microbiol, Mol. Biol. Rev, vol.77, pp.323-341, 2013. ,
Catalytic properties of Na(+)-translocating V-ATPase in Enterococcus hirae, Biochim. Biophys. Acta, vol.1505, pp.75-81, 2001. ,
, , 2016.
, CodY-dependent regulation of sporulation in Clostridium difficile, J. Bacteriol, vol.198, pp.2113-2130
Microbiota-liberated host sugars facilitate postantibiotic expansion of enteric pathogens, Nature, vol.502, pp.96-99, 2013. ,
YidC1 and YidC2 are functionally distinct proteins involved in protein secretion, biofilm formation and cariogenicity of Streptococcus mutans, Microbiology, vol.158, pp.1702-1712, 2012. ,
Biofilms of Clostridium species, Anaerobe, vol.30, pp.193-198, 2014. ,
The Clostridium difficile protease Cwp84 modulates both biofilm formation and cell-surface properties, PLoS One, vol.10, p.124971, 2015. ,
Spo0A links de novo fatty acid synthesis to sporulation and biofilm development in Bacillus subtilis, Mol. Microbiol, vol.87, pp.348-367, 2013. ,
Cyclic diGMP regulates production of sortase substrates of Clostridium difficile and their surface exposure through ZmpI proteasemediated cleavage, J. Biol. Chem, vol.290, pp.24453-24469, 2015. ,
Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism, BMC Genomics, vol.15, p.160, 2014. ,
Regulation of Type IV Pili contributes to surface behaviors of historical and epidemic strains of Clostridium difficile, J. Bacteriol, vol.198, pp.565-577, 2015. ,
A nutrient-regulated cyclic diguanylate phosphodiesterase controls Clostridium difficile biofilm and toxin production during stationary phase, Infect. Immun, vol.85, pp.347-364, 2017. ,
Cyclic diguanylate inversely regulates motility and aggregation in Clostridium difficile, J. Bacteriol, vol.194, pp.3307-3316, 2012. ,
Structural characterization of surface glycans from Clostridium difficile, Carbohydr. Res, vol.354, pp.65-73, 2012. ,
Gene expression in Bacillus subtilis surface biofilms with and without sporulation and the importance of yveR for biofilm maintenance, Biotechnol. Bioeng, vol.86, pp.344-364, 2004. ,
Inactivation of the SecA2 protein export pathway in Listeria monocytogenes promotes cell aggregation, impacts biofilm architecture and induces biofilm formation in environmental condition, Environ. Microbiol, vol.16, pp.1176-1192, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01204380
Differential gene expression profiling of Staphylococcus aureus cultivated under biofilm and planktonic conditions, Appl. Environ. Microbiol, vol.71, pp.2663-2676, 2005. ,
Regulating the intersection of metabolism and pathogenesis in Gram-positive bacteria, 2015. ,
, , vol.3, pp.4-2014
The key sigma factor of transition phase, SigH, controls sporulation, metabolism, and virulence factor expression in Clostridium difficile, J. Bacteriol, vol.193, pp.3186-3196, 2011. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01370840
Genome-wide analysis of cell type-specific gene transcription during spore formation in Clostridium difficile, PLoS Genet, vol.9, p.1003756, 2013. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01370780
Autotrophy at the thermodynamic limit of life: a model for energy conservation in acetogenic bacteria, Nat. Rev. Microbiol, vol.12, pp.809-821, 2014. ,
Spore formation and toxin production in Clostridium difficile biofilms, PLoS One, vol.9, p.87757, 2014. ,
Analysis of bacterial communities during Clostridium difficile infection in the mouse, Infect. Immun, vol.83, pp.4383-4391, 2015. ,
Identification of the Streptococcus gordonii glmM gene encoding phosphoglucosamine mutase and its role in bacterial cell morphology, biofilm formation, and sensitivity to antibiotics, FEMS Immunol. Med. Microbiol, vol.53, pp.166-177, 2008. ,
, , 2016.
, Clostridium difficile infection, Nat. Rev. Dis. Primers, vol.2, p.16020
Biofilm structures in a mono-associated mouse model of Clostridium difficile, Infection. Front. Microbiol, vol.8, p.2086, 2017. ,
Genome-wide identification of regulatory RNAs in the human pathogen Clostridium difficile, PLoS Genet, vol.9, p.1003493, 2013. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01370770
Interactions between the gastrointestinal microbiome and Clostridium difficile, Annu. Rev. Microbiol, vol.69, pp.445-461, 2015. ,
Role of glycosyltransferases modifying type B flagellin of emerging hypervirulent Clostridium difficile lineages and their impact on motility and biofilm formation, J. Biol. Chem, vol.291, pp.25450-25461, 2016. ,
SarA and not sigmaB is essential for biofilm development by Staphylococcus aureus, Microbiol. Spectr, vol.48, pp.1075-1087, 2003. ,
D-alanyl ester depletion of teichoic acids in Lactobacillus reuteri 100-23 results in impaired colonization of the mouse gastrointestinal tract, Environ. Microbiol, vol.9, pp.1750-1760, 2007. ,
Clostridium difficile surface proteins are anchored to the cell wall using CWB2 motifs that recognise the anionic polymer PSII, Mol. Microbiol, vol.96, pp.596-608, 2015. ,
Membrane lipid homeostasis in bacteria, Nat. Rev. Microbiol, vol.6, pp.222-233, 2008. ,