Cucurbit[5]uril derivatives as oxygen carriers - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Supramolecular Chemistry Year : 2019

Cucurbit[5]uril derivatives as oxygen carriers


Cucurbit[n]urils are rigid cage-molecules of pumpkin-like shape, made of n-glycoluril units, able to bind mainly neutral molecules and cations. In this work, we investigate the binding of three cucurbit[5]uril derivatives with dioxygen O$_2$ and show that one of them, namely per-hydroxylated cucurbit[5]uril, (OH)$_{10}$CB[5], is able to significantly bind dioxygen gas at physiological temperature, even in the presence of sodium chloride at the concentration of injectable solution in blood. As cucurbit[n]urils studied up to now reveal low toxicity, per-hydroxylated cucurbit[5]uril appears as a promising precursor to design a host able to transport O$_2$ in a haemoglobin substitute solution.
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cea-02273187 , version 1 (28-08-2019)



Gaspard Huber, Patrick Berthault, Anvi Laetitia Nguyen, Alain Pruvost, Elodie Barruet, et al.. Cucurbit[5]uril derivatives as oxygen carriers. Supramolecular Chemistry, 2019, 31 (10), pp.668-675. ⟨10.1080/10610278.2019.1655565⟩. ⟨cea-02273187⟩
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