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Bioavailability and its assessment.

Abstract : Bioavailability is a key pharmacokinetic parameter which expresses the proportion of a drug administered by any nonvascular route that gains access to the systemic circulation. Presented in this review are the different approaches to measurement of bioavailability (absolute and relative), including the case in which intravenous administration is impossible. The rate of drug absorption is also discussed with special emphasis on the possible difficulties encountered using C(max) and T(max) or curve fitting to evaluate the rate of drug absorption.
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Contributor : Alain Bousquet-Mélou Connect in order to contact the contributor
Submitted on : Tuesday, September 14, 2010 - 10:25:09 PM
Last modification on : Wednesday, June 1, 2022 - 3:41:39 AM

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Pierre-Louis Toutain, Alain Bousquet‐mélou. Bioavailability and its assessment.. Journal of Veterinary Pharmacology and Therapeutics, Wiley-Blackwell, 2004, 27 (6), pp.455-66. ⟨10.1111/j.1365-2885.2004.00604.x⟩. ⟨hal-00517568⟩



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