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Thirteen-year prospective study between fish consumption, long-chain n-3 fatty acids intakes and cognitive function.

Abstract : OBJECTIVES: Because of their structural, anti-inflammatory and antithrombic properties, long-chain n-3 fatty acids may be key factors in the aging process. We sought to elucidate the association between intake of long-chain n-3 fatty acids and/or fish and cognitive function evaluated 13 years after dietary assessment. DESIGN: Prospective population-based study. PARTICIPANTS/SETTING: 3,294 adults from the SU.VI.MAX study (Supplementation with Antioxidant Vitamins and Minerals study). MEASUREMENTS/STATISTICAL ANALYSIS: Subjects underwent a standardized clinical examination which included cognitive tests and self-reported cognitive difficulties scale (2007-2009). Poor scores were defined using percentiles as cut-off. Dietary data were assessed through repeated 24-h dietary records. Odd ratio (OR), comparing the fourth (Q4) to the first quartile (Q1), of having a poor score were calculated using adjusted logistic regression. RESULTS: Self-reported cognitive difficulties were less frequent among subjects with higher intakes of total n-3 long chain fatty acids (OR = 0.72, CI 95%=0.56-0.92) and eicosapentaenoic acid (OR Q4 versus Q1 = 0.74, CI 95%=0.58-0.95), even after adjustment for depressive symptoms. A borderline significant association was also found with high fish consumption (OR Q4 versus Q1 = 0.80, CI 95%=0.63-1.01). CONCLUSION: Cognitive complaints, which may be an early indicator of cognitive decline, are less frequent among the elderly who have a high long-chain n-3 acids intake, as assessed 13 years earlier.
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https://hal-unilim.archives-ouvertes.fr/hal-00626655
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Submitted on : Monday, September 26, 2011 - 4:32:29 PM
Last modification on : Tuesday, May 17, 2022 - 12:20:02 PM

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Emmanuelle Kesse-Guyot, S. Péneau, M. Ferry, Claude Jeandel, S. Hercberg, et al.. Thirteen-year prospective study between fish consumption, long-chain n-3 fatty acids intakes and cognitive function.. Journal of Nutrition, Health and Aging, Springer Verlag (Germany), 2011, 15 (2), pp.115-20. ⟨10.1007/s12603-011-0023-7⟩. ⟨hal-00626655⟩

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