HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Tenectin is a novel alphaPS2betaPS integrin ligand required for wing morphogenesis and male genital looping in Drosophila.

Abstract : Morphogenesis of the adult structures of holometabolous insects is regulated by ecdysteroids and juvenile hormones and involves cell-cell interactions mediated in part by the cell surface integrin receptors and their extracellular matrix (ECM) ligands. These adhesion molecules and their regulation by hormones are not well characterized. We describe the gene structure of a newly described ECM molecule, tenectin, and demonstrate that it is a hormonally regulated ECM protein required for proper morphogenesis of the adult wing and male genitalia. Tenectin's function as a new ligand of the PS2 integrins is demonstrated by both genetic interactions in the fly and by cell spreading and cell adhesion assays in cultured cells. Its interaction with the PS2 integrins is dependent on RGD and RGD-like motifs. Tenectin's function in looping morphogenesis in the development of the male genitalia led to experiments that demonstrate a role for PS integrins in the execution of left-right asymmetry.
Document type :
Journal articles
Complete list of metadata

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-00761472
Contributor : Sabine Julien Connect in order to contact the contributor
Submitted on : Wednesday, December 5, 2012 - 3:28:07 PM
Last modification on : Friday, February 18, 2022 - 3:02:40 AM

Links full text

Identifiers

Collections

Citation

Stéphane Fraichard, Anne-Laure Bougé, Timmy Kendall, Isabelle Chauvel, Hervé Bouhin, et al.. Tenectin is a novel alphaPS2betaPS integrin ligand required for wing morphogenesis and male genital looping in Drosophila.. Developmental Biology, Elsevier, 2010, 340 (2), pp.504-17. ⟨10.1016/j.ydbio.2010.02.008⟩. ⟨hal-00761472⟩

Share

Metrics

Record views

69