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Antifungal properties of durancins isolated from Enterococcus durans A5-11 and of its synthetic fragments.
Abstract : The aim of this work was to study the antifungal properties of durancins isolated from Enterococcus durans A5-11 and of their chemically synthesized fragments. Enterococcus durans A5-11 is a lactic acid bacteria strain isolated from traditional Mongolian airag cheese. This strain inhibits the growth of several fungi including Fusarium culmorum, Penicillium roqueforti and Debaryomyces hansenii. It produces two bacteriocins: durancin A5-11a and durancin A5-11b, which have similar antimicrobial properties. The whole durancins A5-11a and A5-11b, as well as their N- and C-terminal fragments were synthesized, and their antifungal properties were studied. C-terminal fragments of both durancins showed stronger antifungal activities than other tested peptides. Treatment of D. hansenii LMSA2.11.003 strain with 2 mmol l(-1) of the synthetic peptides led to the loss of the membrane integrity and to several changes in the ultra-structure of the yeast cells. Chemically synthesized durancins and their synthetic fragments showed different antimicrobial properties from each other. N-terminal peptides show activities against both bacterial and fungal strains tested. C-terminal peptides have specific activities against tested fungal strain and do not show antibacterial activity. However, the C-terminal fragment enhances the activity of the N-terminal fragment in the whole bacteriocins against bacteria.
https://hal.univ-brest.fr/hal-00817052
Déposant : Adminhal Univbrestbu <>
Soumis le : mardi 23 avril 2013 - 16:07:43
Dernière modification le : mardi 12 janvier 2021 - 16:49:24
Déposant : Adminhal Univbrestbu <>
Soumis le : mardi 23 avril 2013 - 16:07:43
Dernière modification le : mardi 12 janvier 2021 - 16:49:24
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