Skip to Main content Skip to Navigation
New interface
Journal articles

The ABO blood group is a trans-species polymorphism in primates

Abstract : The ABO histo-blood group, the critical determinant of transfusion incompatibility, was the first genetic polymorphism discovered in humans. Remarkably, ABO antigens are also polymorphic in many other primates, with the same two amino acid changes responsible for A and B specificity in all species sequenced to date. Whether this recurrence of A and B antigens is the result of an ancient polymorphism maintained across species or due to numerous, more recent instances of convergent evolution has been debated for decades, with a current consensus in support of convergent evolution. We show instead that genetic variation data in humans and gibbons as well as in Old World monkeys are inconsistent with a model of convergent evolution and support the hypothesis of an ancient, multiallelic polymorphism of which some alleles are shared by descent among species. These results demonstrate that the A and B blood groups result from a trans-species polymorphism among distantly related species and has remained under balancing selection for tens of millions of years-to date, the only such example in hominoids and Old World monkeys outside of the major histocompatibility complex.
Document type :
Journal articles
Complete list of metadata

Cited literature [56 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-00956369
Contributor : Archive Ouverte ProdInra Connect in order to contact the contributor
Submitted on : Tuesday, May 7, 2019 - 2:01:34 PM
Last modification on : Tuesday, May 31, 2022 - 10:20:16 AM
Long-term archiving on: : Tuesday, October 1, 2019 - 8:38:57 PM

File

18493.full.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Laure L. Segurel, Emma E. E. E. Thompson, Timothée T. Flutre, Jessica J. Lovstad, Aarti A. Venkat, et al.. The ABO blood group is a trans-species polymorphism in primates. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (45), pp.18493 - 18498. ⟨10.1073/pnas.1210603109⟩. ⟨hal-00956369⟩

Share

Metrics

Record views

81

Files downloads

30