Novel insights into the bovine polled phenotype and horn ontogenesis in Bovidae
Aurélie Allais-Bonnet
(1)
,
Cécile Grohs
(2)
,
Ivica I. Medugorac
(3)
,
Stefan S. Krebs
(4)
,
Anis Djari
(5)
,
Alexander A. Graf
(4)
,
Sebastien S. Fritz
(2)
,
Doris D. Seichter
,
Aurélia A. Baur
(2)
,
Ingolf I. Russ
,
Stephan S. Bouet
(2)
,
Sophie S. Rothammer
(3)
,
Per P. Wahlberg
(2)
,
Diane D. Esquerre
(6)
,
Chris Hoze Hoze
(2)
,
Mekki Boussaha
(2)
,
Bernard B. Weiss
(2)
,
Dominique Thepot Thépot
(1)
,
Marie-Noëlle M.-N. Fouilloux
,
Marie-Noëlle M.-N. Rossignol
(7)
,
Este E. van Marle-Köster
(8)
,
Gunnfríður G. Elín Hreiðarsdóttir
,
Sarah S. Barbey
(9)
,
Dominique D. Dozias
(9)
,
Emilie Cobo
(9)
,
Patrick P. Reversé
,
Olivier O. Catros
,
Jean-Luc J.-L. Marchand
,
Pascal P. Soulas
,
Pierre P. Roy
,
Brigitte B. Marquant-Leguienne
,
Daniel D. Le Bourhis
(1)
,
Laetitia L. Clément
,
Laura L. Salas-Cortes
,
Eric Venot
(2)
,
Maëlle Pannetier
(1)
,
Florence Phocas
(2)
,
Christophe C. Klopp
(5)
,
Dominique Rocha
(2)
,
Michel M. Fouchet
,
Laurent L. Journaux
,
Carine C. Bernard-Capel
,
Claire C. Ponsart
,
Andre A. Eggen
(2)
,
Helmut H. Blum
(4)
,
Yves Y. Gallard
(9)
,
Didier Boichard
(2)
,
Eric Pailhoux
(1)
,
Aurelien A. Capitan
(2)
1
BDR -
Biologie du développement et reproduction
2 GABI - Génétique Animale et Biologie Intégrative
3 Chair of Animal Genetics and Husbandry
4 Laboratory for Functional Genome Analysis, Gene Center
5 UBIA - Unité de Biométrie et Intelligence Artificielle (ancêtre de MIAT)
6 LGC - Laboratoire de Génétique Cellulaire
7 LABOGENA - Laboratoire d'Analyse Génétique pour les Espèces Animales
8 Department of Animal & Wildlife Sciences
9 DEP - Domaine Expérimental du Pin
2 GABI - Génétique Animale et Biologie Intégrative
3 Chair of Animal Genetics and Husbandry
4 Laboratory for Functional Genome Analysis, Gene Center
5 UBIA - Unité de Biométrie et Intelligence Artificielle (ancêtre de MIAT)
6 LGC - Laboratoire de Génétique Cellulaire
7 LABOGENA - Laboratoire d'Analyse Génétique pour les Espèces Animales
8 Department of Animal & Wildlife Sciences
9 DEP - Domaine Expérimental du Pin
Aurélie Allais-Bonnet
- Function : Author
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- IdHAL : aurelie-allais-bonnet
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Cécile Grohs
- Function : Author
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Anis Djari
- Function : Author
- PersonId : 974345
- ORCID : 0000-0002-9093-440X
Doris D. Seichter
- Function : Author
Ingolf I. Russ
- Function : Author
Diane D. Esquerre
- Function : Author
- PersonId : 1203847
- ORCID : 0000-0001-6646-1932
Mekki Boussaha
- Function : Author
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- IdHAL : mekki-boussaha
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Dominique Thepot Thépot
- Function : Author
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Marie-Noëlle M.-N. Fouilloux
- Function : Author
Gunnfríður G. Elín Hreiðarsdóttir
- Function : Author
Sarah S. Barbey
- Function : Author
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Emilie Cobo
- Function : Author
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Patrick P. Reversé
- Function : Author
Olivier O. Catros
- Function : Author
Jean-Luc J.-L. Marchand
- Function : Author
Pascal P. Soulas
- Function : Author
Pierre P. Roy
- Function : Author
Brigitte B. Marquant-Leguienne
- Function : Author
Laetitia L. Clément
- Function : Author
Laura L. Salas-Cortes
- Function : Author
Eric Venot
- Function : Author
- PersonId : 1238089
- IdHAL : eric-venot
- ORCID : 0009-0006-4317-5822
Maëlle Pannetier
- Function : Author
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- IdRef : 100506054
Florence Phocas
- Function : Author
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- IdHAL : florence-phocas
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- IdRef : 144550202
Christophe C. Klopp
- Function : Author
- PersonId : 735911
- IdHAL : 0000-0001-7126-5477
- ORCID : 0000-0001-7126-5477
Dominique Rocha
- Function : Author
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- IdHAL : dominique-rocha
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- IdRef : 183665732
Michel M. Fouchet
- Function : Author
Laurent L. Journaux
- Function : Author
Carine C. Bernard-Capel
- Function : Author
Claire C. Ponsart
- Function : Author
- PersonId : 1168811
- IdHAL : ponsart-claire
- ORCID : 0000-0002-9633-4464
- IdRef : 172260310
Didier Boichard
- Function : Author
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- IdHAL : didier-boichard
- ORCID : 0000-0003-0361-2961
- IdRef : 132520087
Eric Pailhoux
- Function : Author
- PersonId : 743079
- IdHAL : eric-pailhoux
- ORCID : 0000-0001-8012-9143
- IdRef : 100506178
Abstract
Despite massive research efforts, the molecular etiology of bovine polledness and the developmental pathways involved in horn ontogenesis are still poorly understood. In a recent article, we provided evidence for the existence of at least two different alleles at the Polled locus and identified candidate mutations for each of them. None of these mutations was located in known coding or regulatory regions, thus adding to the complexity of understanding the molecular basis of polledness. We confirm previous results here and exhaustively identify the causative mutation for the Celtic allele (PC) and four candidate mutations for the Friesian allele (PF). We describe a previously unreported eyelash-and-eyelid phenotype associated with regular polledness, and present unique histological and gene expression data on bovine horn bud differentiation in fetuses affected by three different horn defect syndromes, as well as in wild-type controls. We propose the ectopic expression of a lincRNA in PC/p horn buds as a probable cause of horn bud agenesis. In addition, we provide evidence for an involvement of OLIG2, FOXL2 and RXFP2 in horn bud differentiation, and draw a first link between bovine, ovine and caprine Polled loci. Our results represent a first and important step in understanding the genetic pathways and key process involved in horn bud differentiation in Bovidae.
Domains
Agricultural sciences
Origin : Publisher files allowed on an open archive
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