Non-coding RNAs revealed during identification of genes involved in chicken immune responses - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Immunogenetics Year : 2009

Non-coding RNAs revealed during identification of genes involved in chicken immune responses

Abstract

Recent large-scale cDNA cloning studies have shown that a significant proportion of the transcripts expressed from vertebrate genomes do not appear to encode protein. Moreover, it was reported in mammals (human and mice) that these non-coding transcripts are expressed and regulated by mechanisms similar to those involved in the control of protein-coding genes. We have produced a collection of cDNA sequences from immunologically active tissues with the aim of discovering chicken genes involved in immune mechanisms, and we decided to explore the non-coding component of these immune-related libraries. After finding known non-coding RNAs (miRNA, snRNA, snoRNA), we identified new putative mRNA-like non-coding RNAs. We characterised their expression profiles in immune-related samples. Some of them showed changes in expression following viral infections. As they exhibit patterns of expression that parallel the behaviour of protein-coding RNAs in immune tissues, our study suggests that they could play an active role in the immune response.

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hal-01193437 , version 1 (04-09-2015)

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Marie-Laure Endale Ahanda, Thomas Ruby, Håkan Wittzell, Bertrand Bed'Hom, Anne-Marie Chaussé, et al.. Non-coding RNAs revealed during identification of genes involved in chicken immune responses. Immunogenetics, 2009, 61 (1), pp.55-70. ⟨10.1007/s00251-008-0337-8⟩. ⟨hal-01193437⟩
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