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Article Dans Une Revue Investigative Ophthalmology & Visual Science Année : 2016

Relationships of Macular Pigment Optical Density With Plasma Lutein, Zeaxanthin, and Diet in an Elderly Population

Résumé

PURPOSE. To investigate the association of macular pigment optical density (MPOD) with plasma lutein, zeaxanthin, and diet in an elderly population. METHODS. We conducted a population-based study, the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular, and HEarT disease) study, in subjects older than 75 years. The MPOD was measured by means of the two-wavelength autofluorescence technique. Plasma lutein and zeaxanthin were measured in fasting blood samples using HPLC. Food frequency consumption was assessed with self-reported food frequency questionnaires. RESULTS. Overall, 433 healthy participants (62.1% females) were included. Mean age was 82.0 +/- 3.6 years. Mean MPOD at 0.5 degrees eccentricity was 0.57 +/- 0.25 density units (DU) and was higher in women than in men (0.59 +/- 0.25 vs. 0.53 +/- 0.25, P = 0.017). The MPOD was lower in alcohol consumers than in non-alcohol consumers (0.55 +/- 0.25 vs. 0.61 +/- 0.25, P = 0.016). Median plasma lutein and zeaxanthin levels were 281.4 mu g/L and 20.0 mu g/L, respectively, and were higher in women (P = 0.010 and P = 0.003, respectively). The MPOD was positively correlated with plasma lutein and zeaxanthin (r = 0.10, P = 0.030 and r = 0.11, P = 0.027, respectively). A higher consumption of squash was associated with higher plasma lutein and zeaxanthin. Adjusting for confounders and diet revealed that MPOD was weakly associated with plasma lutein in nonsmokers (beta = 0.11, P = 0.021). CONCLUSIONS. This study suggests that plasma lutein is associated with MPOD after taking into account potential confounding factors in an elderly population.
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Dates et versions

hal-01399918 , version 1 (26-09-2017)

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Seydou Alassane, Christine Binquet, Vanessa Cottet, Olivier Fleck, Niyazi Acar, et al.. Relationships of Macular Pigment Optical Density With Plasma Lutein, Zeaxanthin, and Diet in an Elderly Population: The Montrachet Study. Investigative Ophthalmology & Visual Science, 2016, 57 (3), pp.1160-1167. ⟨10.1167/iovs.15-18007⟩. ⟨hal-01399918⟩
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