Conversion to no-till (NT) is usually associated to increased soil organic carbon (SOC) stocks in comparison to inversion tillage (IT). However, an important and unexplained variability in the changes in SOC with NT adoption exists, which impedes accurate prediction of its potential for C sequestration. We performed a meta-analysis with pedo-climatic and crop factors observed to influence SOC storage under NT at local and regional scales, in order to determine those better explaining this variability at a global scale. We studied SOC stocks (0-30 cm) in an equivalent soil mass, climatic and soil characteristics in 92 NT-IT paired cases. A sub-base with the 35 pairs providing C inputs was used to test their effect. Greater SOC stocks were observed with NT, with a smaller difference than often described (6.7%, i.e. 3.4 Mg C ha(-1)). Crop C inputs differences was the only factor significantly and positively related to SOC stock differences between NT and IT, explaining 30% of their variability. The variability in SOC storage induced by NT conversion seems largely related to the variability of the crop production response. Changes at the agro-ecosystem level, not only in soil, should be considered when assessing the potential of NT for C sequestration.