This paper aims at assessing the sustainability of development in eleven Latin American countries. For that purpose, we establish an evaluation index system grouped into four subsystems (economic subsystem, social subsystem, ecologic subsystem and institutional subsystem). The weights for the index subsystems of sustainable development are based on the concept of entropy. The empirical results show that the sustainable development strategy in this group of countries is not efficient and is characterized by a lack of coordination between the four dimensions. This quantitative evaluation provides a new perspective for research in sustainable development researches and guidance for public policies.