Skip to Main content Skip to Navigation
Journal articles

Responses to auxin signals: an operating principle for dynamical sensitivity yet high resilience

Abstract : Plants depend on the signaling of the phytohormone auxin for their development and for responding to environmental perturbations. The associated biomolecular signaling network involves a negative feedback at the level of the Aux/IAA proteins which mediate the influence of auxin (the signal) on the ARF transcription factors (the drivers of the response). To probe the role of this feedback, we consider alternative in silico signaling networks implementing different operating principles. By a comparative analysis, we find that the presence of a negative regulatory feedback loop allows the system to have a far larger sensitivity in its dynamical response to auxin. At the same time, this sensitivity does not prevent the system from being highly resilient. Given this insight, we reconsider previously published models and build a new quantitative and calibrated biomolecular model of auxin signaling.
Document type :
Journal articles
Complete list of metadata

Cited literature [35 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-01735356
Contributor : Claudine Le Vaou <>
Submitted on : Tuesday, May 26, 2020 - 2:59:48 AM
Last modification on : Thursday, May 6, 2021 - 10:46:36 AM

File

2017_Grigolon_Royal Society Op...
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Silvia Grigolon, Barbara Bravi, Olivier C. Martin. Responses to auxin signals: an operating principle for dynamical sensitivity yet high resilience. Royal Society Open Science, The Royal Society, 2018, 5 (1), pp.1-15. ⟨10.1098/rsos.172098⟩. ⟨hal-01735356⟩

Share

Metrics

Record views

565

Files downloads

69