Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue Cell Metabolism Année : 2018

Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance

Konstantinos Voutetakis
  • Fonction : Auteur
Aristotelis Chatziioannou
  • Fonction : Auteur
John B Patterson
  • Fonction : Auteur
Eric Chevet

Résumé

Dietary restriction (DR) was shown to impact on tumor growth with very variable effects depending on the cancer type. However, how DR limits cancer progression remains largely unknown. Here, we demonstrate that feeding mice a low-protein (Low PROT) isocaloric diet but not a low-carbohydrate (Low CHO) diet reduced tumor growth in three independent mouse cancer models. Surprisingly, this effect relies on anticancer immunosurveillance, as depleting CD8 T cells, antigen-presenting cells (APCs), or using immunodeficient mice prevented the beneficial effect of the diet. Mechanistically, we established that a Low PROT diet induces the unfolded protein response (UPR) in tumor cells through the activation of IRE1α and RIG1 signaling, thereby resulting in cytokine production and mounting an efficient anticancer immune response. Collectively, our data suggest that a Low PROT diet induces an IRE1α-dependent UPR in cancer cells, enhancing a CD8-mediated T cell response against tumors.

Domaines

Cancer Chimie

Dates et versions

hal-01778379 , version 1 (25-04-2018)

Identifiants

Citer

Camila Rubio-Patiño, Jozef P Bossowski, Gian Marco de Donatis, Laura Mondragón, Elodie Villa, et al.. Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance. Cell Metabolism, 2018, 27 (4), pp.828-842.e7. ⟨10.1016/j.cmet.2018.02.009⟩. ⟨hal-01778379⟩
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