Skip to Main content Skip to Navigation
Journal articles

α-Galactosidase/Sucrose Kinase (AgaSK), a Novel Bifunctional Enzyme from the Human Microbiome Coupling Galactosidase and Kinase Activities

Abstract : Background: Raffinose, an abundant carbohydrate in plants, is degraded into galactose and sucrose by intestinal microbial enzymes. Results: AgaSK is a protein coupling galactosidase and sucrose kinase activity. The structure of the galactosidase domain sheds light onto substrate recognition. Conclusion: AgaSK produces sucrose-6-phosphate directly from raffinose. Significance: Production of sucrose-6-phosphate directly from raffinose points toward a novel glycolytic pathway in bacteria.
Document type :
Journal articles
Complete list of metadata

Cited literature [44 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-01793279
Contributor : Renaud Hardré Connect in order to contact the contributor
Submitted on : Wednesday, May 16, 2018 - 2:09:16 PM
Last modification on : Monday, July 4, 2022 - 8:46:32 AM
Long-term archiving on: : Tuesday, September 25, 2018 - 10:00:37 PM

File

Bruel et al. 2011 J Biol Chem....
Publisher files allowed on an open archive

Licence

Copyright

Identifiers

Citation

Laëtitia Bruel, Gerlind Sulzenbacher, Marine Cervera Tison, Ange Pujol, Cendrine Nicoletti, et al.. α-Galactosidase/Sucrose Kinase (AgaSK), a Novel Bifunctional Enzyme from the Human Microbiome Coupling Galactosidase and Kinase Activities. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2011, 286 (47), pp.40814 - 40823. ⟨10.1074/jbc.M111.286039⟩. ⟨hal-01793279⟩

Share

Metrics

Record views

84

Files downloads

64