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Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress

Abstract : Skeletal muscle atrophy is a common feature of numerous chronic pathologies and is correlated with patient mortality. The REDD1 protein is currently recognized as a negative regulator of muscle mass through inhibition of the Akt/mTORC1 signaling pathway. REDD1 expression is notably induced following glucocorticoid secretion, which is a component of energy stress responses.
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https://hal.umontpellier.fr/hal-01815521
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Submitted on : Tuesday, December 3, 2019 - 11:17:42 AM
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Florian A Britto, Fabienne Cortade, Yassine Belloum, Marine Blaquière, Yann Gallot, et al.. Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress. BMC Biology, 2018, 16 (1), pp.65. ⟨10.1186/s12915-018-0525-4⟩. ⟨hal-01815521⟩

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