Lack of Hypothalamus Polysialylation Inducibility Correlates With Maladaptive Eating Behaviors and Predisposition to Obesity - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Frontiers in Nutrition Year : 2018

Lack of Hypothalamus Polysialylation Inducibility Correlates With Maladaptive Eating Behaviors and Predisposition to Obesity

Gaëlle Boudry

Abstract

High variability exists in individual susceptibility to develop overweight in an obesogenic environment and the biological underpinnings of this heterogeneity are poorly understood. In this brief report, we show in mice that the vulnerability to diet-induced obesity is associated with low level of polysialic acid-neural cell adhesion molecule (PSA-NCAM), a factor of neural plasticity, in the hypothalamus. As we previously shown that reduction of hypothalamic PSA-NCAM is sufficient to alter energy homeostasis and promote fat storage under hypercaloric pressure, inter-individual variability in hypothalamic PSA-NCAM might account for the vulnerability to diet-induced obesity. These data support the concept that reduced plasticity in brain circuits that control appetite, metabolism and body weight confers risk for eating disorders and obesity.
Fichier principal
Vignette du fichier
pdf (748.29 Ko) Télécharger le fichier
Origin Publisher files allowed on an open archive

Dates and versions

hal-01998042 , version 1 (16-07-2019)

Licence

Identifiers

Cite

Xavier Brenachot, Emmanuelle Nedelec, Selma Ben Fradj, Gaëlle Boudry, Véronique Douard, et al.. Lack of Hypothalamus Polysialylation Inducibility Correlates With Maladaptive Eating Behaviors and Predisposition to Obesity. Frontiers in Nutrition, 2018, 5, pp.125. ⟨10.3389/fnut.2018.00125⟩. ⟨hal-01998042⟩
154 View
42 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More