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A secreted metal-binding protein protects necrotrophic phytopathogens from reactive oxygen species

Abstract : Few secreted proteins involved in plant infection common to necrotrophic bacteria, fungi and oomycetes have been identified except for plant cell wall-degrading enzymes. Here we study a family of iron-binding proteins that is present in Gram-negative and Gram-positive bacteria, fungi, oomycetes and some animals. Homolog proteins in the phytopathogenic bacterium Dickeya dadantii (IbpS) and the fungal necrotroph Botrytis cinerea (BcIbp) are involved in plant infection. IbpS is secreted, can bind iron and copper, and protects the bacteria against H 2 O 2-induced death. Its 1.7 Å crystal structure reveals a classical Venus Fly trap fold that forms dimers in solution and in the crystal. We propose that secreted Ibp proteins binds exogenous metals and thus limit intracellular metal accumulation and ROS formation in the microorganisms.
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https://hal.archives-ouvertes.fr/hal-02336631
Déposant : Agnès Rodrigue <>
Soumis le : mardi 29 octobre 2019 - 08:46:54
Dernière modification le : vendredi 25 septembre 2020 - 09:52:02
Archivage à long terme le : : jeudi 30 janvier 2020 - 14:17:22

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Lulu Liu, Virginie Gueguen-Chaignon, Isabelle R. Gonçalves, Christine Rascle, Martine Rigault, et al.. A secreted metal-binding protein protects necrotrophic phytopathogens from reactive oxygen species. Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.4853. ⟨10.1038/s41467-019-12826-x⟩. ⟨hal-02336631⟩

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