Skip to Main content Skip to Navigation
Journal articles

Models for cell-free synthetic biology: Make prototyping easier, better, and faster

Abstract : Cell-free TX-TL is an increasingly mature and useful platform for prototyping, testing, and engineering biological parts and systems. However, to fully accomplish the promises of synthetic biology, mathematical models are required to facilitate the design and predict the behavior of biological components in cell-free extracts. We review here the latest models accounting for transcription, translation, competition, and depletion of resources as well as genome scale models for lysate-based cell-free TX-TL systems, including their current limitations. These models will have to find ways to account for batch-to-batch variability before being quantitatively predictive in cell-free lysate-based platforms.
Document type :
Journal articles
Complete list of metadata

Cited literature [31 references]  Display  Hide  Download
Contributor : Migration ProdInra Connect in order to contact the contributor
Submitted on : Tuesday, May 26, 2020 - 2:32:12 AM
Last modification on : Friday, August 5, 2022 - 2:38:10 PM


2018_Koch_frontiers in Bioengi...
Publisher files allowed on an open archive


Distributed under a Creative Commons Attribution 4.0 International License



Mathilde Koch, Jean-Loup Faulon, Olivier Borkowski. Models for cell-free synthetic biology: Make prototyping easier, better, and faster. Frontiers in Bioengineering and Biotechnology, Frontiers, 2018, 6, pp.1-6. ⟨10.3389/fbioe.2018.00182⟩. ⟨hal-02621501⟩



Record views


Files downloads