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Role of systemic infection, cross contaminations and super-shedders in Salmonella carrier state in chicken

Abstract : Carriage of Salmonella is often associated with a high level of bacterial excretion and generally occurs after a short systemic infection. However, we do not know whether this systemic infection is required or whether the carrier-state corresponds to continuous reinfection or real persistence in caecal tissue. The use of a Salmonella Enteritidis bamB mutant demonstrated that a carrier-state could be obtained in chicken in the absence of systemic infection. The development of a new infection model in isolator showed that a marked decrease in animal reinfection and host-to-host transmission between chicks led to a heterogeneity of S. Enteritidis excretion and colonization contrary to what was observed in cages. This heterogeneity of infection was characterized by the presence of super-shedders, which constantly disseminated Salmonella to the low-shedder chicks, mainly through airborne movements of contaminated dust particles. The presence of super-shedders, in the absence of host-to-host transmission, demonstrated that constant reinfection was not required to induce a carrier-state. Finally, our results suggest that low-shedder chicks do not have a higher capability to destroy Salmonella but instead can block initial Salmonella colonization. This new paradigm opens new avenues to improve understanding of the carrier-state mechanisms and to define new strategies to control Salmonella infections. This article is protected by copyright. All rights reserved.
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https://hal.inrae.fr/hal-02628240
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Submitted on : Tuesday, May 26, 2020 - 10:33:26 PM
Last modification on : Friday, September 3, 2021 - 11:26:02 AM

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Pierrette Menanteau, Florent Kempf, Jérôme Trotereau, Isabelle Virlogeux-Payant, Edouard Guitton, et al.. Role of systemic infection, cross contaminations and super-shedders in Salmonella carrier state in chicken. Environmental Microbiology, Society for Applied Microbiology and Wiley-Blackwell, 2018, 20 (9), pp.3246-3260. ⟨10.1111/1462-2920.14294⟩. ⟨hal-02628240⟩

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