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Clinical and laboratory features of canine Anaplasma platys infection in 32 naturally infected dogs in the Mediterranean basin

Abstract : Since the first description of Anaplasma platys Infection (ApI), the disease has been sporadically reportedworldwide. Whereas it is considered a subclinical disease in the United States or in Australia, severe casesare reported in Europe. Thus far, little information is available regarding the clinical and laboratory find-ings associated with the disease and the implication of co-infections with other vector-borne pathogens(VBPs) in Southern Europe. The purpose of the study was to describe clinical and laboratory findings inPCR-confirmed naturally infected dogs in the Mediterranean Basin, and to assess the potential impact ofco-infections with other VBPs. This is a retrospective analysis of medical records from 32 client-owneddogs diagnosed with ApI using PCR-based assays. Anorexia (62.5%) and weight loss (43.8%) were the majorchanges, whereas lethargy was less frequent (34.4%). Lymphadenomegaly (43.8%), hyperthermia (40.6%)and hemorrhage (37.5%) were frequent clinical abnormalities, whereas cutaneous signs (31.3%), muscu-loskeletal disorders (21.9%), splenomegaly (15.6%), dehydration and ocular inflammation (12.5%) wereless common. Hematological abnormalities included thrombocytopenia (81.0%), anemia (81.0%), leukocy-tosis (33.3%) and leucopenia (23.8%). Seven dogs (33.3%) were severely thrombocytopenic. Among the 28dogs with complete testing, 15 and 13 were mono- and co-infected, respectively. Co-infections includedEhrlichia canis (3 dogs), Leishmania infantum (4), Babesia vogeli (2) and Hepatozoon canis (5). One dog wasinfected concurrently with Anaplasma platys, Ehrlichia canis and Babesia vogeli. The 1-month mortalityrate was 23.9% and only 38.1% improved. In the univariate analysis the 15 mono- and the 13 co-infecteddogs did not differ regarding the relative frequencies of clinical and laboratory findings. Sequencing andphylogenetic analyses suggested the existence of 2 different groups of strains: one of them might havehigher pathogenicity. In all, ApI was associated with a wide variety of non-specific clinical findings. Themost common laboratory findings were thrombocytopenia and anemia. Co-infections were frequent butappeared of limited clinical impact. The absence of improvement despite appropriate treatment, highfrequency of hemorrhagic disorders, and case fatalities, suggested the existence of pathogenic Europeanstrains supported by subsequent molecular analyses.
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https://hal.inrae.fr/hal-02636013
Déposant : Migration Prodinra <>
Soumis le : mercredi 27 mai 2020 - 19:36:11
Dernière modification le : mercredi 14 octobre 2020 - 03:56:17

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Tarek Bouzouraa, Magalie René-Martellet, Jeanne Chêne, Charalampos Attipa, Isabelle Lebert, et al.. Clinical and laboratory features of canine Anaplasma platys infection in 32 naturally infected dogs in the Mediterranean basin. Ticks and Tick-borne Diseases, Elsevier, 2016, 7 (6), pp.1256-1264. ⟨10.1016/j.ttbdis.2016.07.004⟩. ⟨hal-02636013⟩

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