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Diversity of CRISPR systems in the euryarchaeal Pyrococcales

Abstract : Pyrococcales are members of the order Thermococcales, a group of hyperthermophilic euryarchaea that are frequently found in deep sea hydrothermal vents. Infectious genetic elements, such as plasmids and viruses, remain a threat even in this remote environment and these microorganisms have developed several ways to fight their genetic invaders. Among these are the recently discovered CRISPR systems. In this review, we have combined and condensed available information on genetic elements infecting the Thermococcales and on the multiple CRISPR systems found in the Pyrococcales to fight them. Their organization and mode of action will be presented with emphasis on the Type III-B system that is the only CRISPR system known to target RNA molecules in a process reminiscent of RNA interference. The intriguing case of Pyrococcus abyssi, which is among the rare strains to present a CRISPR system devoid of the universal cas1 and cas2 genes, is also discussed.
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Déposant : Migration Prodinra <>
Soumis le : jeudi 28 mai 2020 - 21:18:19
Dernière modification le : jeudi 10 septembre 2020 - 15:08:10

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Cédric Norais, Annick Moisan, Christine Gaspin, Béatrice Clouet-d'Orval. Diversity of CRISPR systems in the euryarchaeal Pyrococcales. RNA Biology, Taylor & Francis, 2013, 10 (5), pp.659 - 670. ⟨10.4161/rna.23927⟩. ⟨hal-02644106⟩



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