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JSRV (jaagsiekte sheep retrovirus) et cancer du poumon associé chez le mouton

Abstract : JSRV (jaagsiekte sheep retrovirus) is a betaretrovirus, infecting small ruminants. This virus is responsible for the development of pulmonary adenocarcinoma, by the transformation of epithelial cells of the bronchioli and alveoli. This animal cancer is related to human bronchioloalveolar cancer (BAC), a specific form of human lung cancer for which a viral etiology has been proposed for several decades. In small ruminants JSRV interacts with the cells through the Hyal2 receptor. JSRV genome is simple and does not contain already known oncogene. It is now well established that the envelope protein is oncogenic by itself, via the cytoplasmic domain of the transmembrane glycoprotein and some domains of the surface glycoprotein. Activation of the PI3K/Akt and MAPK pathways participates to the envelope-induced transformation. The tumour development is associated with telomerase activation.
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https://hal.inrae.fr/hal-02656495
Contributor : Migration Prodinra <>
Submitted on : Friday, May 29, 2020 - 11:32:28 PM
Last modification on : Saturday, March 6, 2021 - 3:31:16 AM

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  • HAL Id : hal-02656495, version 1
  • PRODINRA : 310840

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Florent Suau, Nicolas Girard, Fabienne Archer, Vincent Cottin, S. Croze, et al.. JSRV (jaagsiekte sheep retrovirus) et cancer du poumon associé chez le mouton. Virologie, John Libbey Eurotext 2006, 10 (4), pp.287-299. ⟨hal-02656495⟩

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