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Top quality embryos at day 2: a prerequisite for single blastocyst transfer? An observational cohort study in women under 36

Abstract : Purpose While extended culture has been considerably improved, some questions remain regarding the application of Single Blastocyst Transfer (SBT). Methods An observational cohort study was undertaken with 456 women under 36 years old and assigned to SBT on a voluntary basis. The main outcome was the cumulative delivery rate per couple according to the number of Top Quality Embryos (TQE) on day 2 (Group 1= >= 2 TQE, Group 2= 1 TQE and Group 3= 0 TQE). Results Rate of transfer and mean number of frozen blastocyts were higher in Group 1 compared to Group 3. As a consequence, the cumulative delivery rate per couple was higher in Group 1 (47.9%) compared to Group 3 (34.9%). Conclusions Single blastocyst transfer combining fresh and frozen cycles, might be a worthwhile strategy irrespective of embryo quality on day 2 providing good delivery rates while keeping the rate of multiple deliveries low.
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https://hal.inrae.fr/hal-02662528
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Submitted on : Sunday, May 31, 2020 - 12:29:19 AM
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Fabrice Guerif, M. Lemseffer, M. Blanchard, Dominique Royère. Top quality embryos at day 2: a prerequisite for single blastocyst transfer? An observational cohort study in women under 36. Journal of Assisted Reproduction and Genetics, Springer Verlag, 2009, 26 (8), pp.443-449. ⟨10.1007/s10815-009-9345-3⟩. ⟨hal-02662528⟩

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