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Dietary N-3 polyunsaturated fatty acids and dry eye

Abstract : Dry eye disease affects 15% of the population over the age of 65 years. It is characterized mainly by inflammation of the ocular surface (tear film, conjunctiva and cornea), which represents a relevant target for therapeutic strategies. The side effects and long-term intolerance of anti-inflammatory drugs give rise to an increasing interest in dietary components exhibiting anti-inflammatory properties, such as polyunsaturated fatty acids. In this chapter, we have exposed the dry eye pathology in terms of prevalence and symptoms. Then we have described the anti-inflammatory role of n-3 polyunsaturated fatty acids and some of their mechanisms of actions. Finally, we have shown the influence of n-3 polyunsaturated fatty acid deficiency and supplementation in dry eye. Our conclusions are on the importance of combining dietary polyunsaturated fatty acids to classical therapies.
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Corinne Joffre, Sabrina Viau. Dietary N-3 polyunsaturated fatty acids and dry eye. Handbook of Nutrition, Diet, and the Eye, Elsevier Ltd, 2014, 978-0-12-401717-7. ⟨10.1016/B978-0-12-401717-7.00018-6⟩. ⟨hal-02795028⟩



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