Recent years have seen the development of many biological control agents and other biopesticides, such as plant extracts, minerals and organic compounds, against Botrytis-incited diseases. This chapter presents significant examples of such commercially available products and reviews our increasing comprehension of mechanisms implicated in biological control, including recent breakthroughs on complex interactions between the biocontrol agent, the host plant and the pathogen. Its highlights progress made in characterizing the determinants of efficacy and documents the growing body of knowledge on natural biological control and the potential for its enhancement. Finally, future prospects and challenges are presented, including issues on the durability of biocontrol methods.