The stability mechanisms of an injectable calcium phosphate ceramic suspension. - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue Journal of Materials Science: Materials in Medicine Année : 2010

The stability mechanisms of an injectable calcium phosphate ceramic suspension.

Résumé

Calcium phosphate ceramics are widely used as bone substitutes in dentistry and orthopedic applications. For minimally invasive surgery an injectable calcium phosphate ceramic suspension (ICPCS) was developed. It consists in a biopolymer (hydroxypropylmethylcellulose: HPMC) as matrix and bioactive calcium phosphate ceramics (biphasic calcium phosphate: BCP) as fillers. The stability of the suspension is essential to this generation of "ready to use" injectable biomaterial. But, during storage, the particles settle down. The engineering sciences have long been interested in models describing the settling (or sedimentation) of particles in viscous fluids. Our work is dedicated to the comprehension of the effect of the formulation on the stability of calcium phosphate suspension before and after steam sterilization. The rheological characterization revealed the macromolecular behavior of the suspending medium. The investigations of settling kinetics showed the influence of the BCP particle size and the HPMC concentration on the settling velocity and sediment compactness before and after sterilization. To decrease the sedimentation process, the granule size has to be smaller and the polymer concentration has to increase. A much lower sedimentation velocity, as compared to Stokes law, is observed and interpreted in terms of interactions between the polymer network in solution and the particles. This experimentation highlights the granules spacer property of hydrophilic macromolecules that is a key issue for interconnection control, one of the better ways to improve osteoconduction and bioactivity.
Fichier principal
Vignette du fichier
inserm-00507125_edited.pdf (573.98 Ko) Télécharger le fichier
The_stability_mechanisms_of_an_injectable_calcium_phosphate_ceramic_suspension-_Revised_manuscript.pdf (4.06 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

inserm-00507125 , version 1 (14-03-2011)

Identifiants

Citer

Ahmed Fatimi, Jean-François Tassin, Monique A. V. Axelos, Pierre Weiss. The stability mechanisms of an injectable calcium phosphate ceramic suspension.. Journal of Materials Science: Materials in Medicine, 2010, 21 (6), pp.1799-809. ⟨10.1007/s10856-010-4047-z⟩. ⟨inserm-00507125⟩
265 Consultations
544 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More