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Journal articles
Association between genetic obesity susceptibility and mother-reported eating behavior in children up to 5 years: genetic obesity risk and child’s eating behavior
Abstract : BACKGROUND:
Many genetic polymorphisms identified by genome-wide association studies for adult body mass index (BMI) have been suggested to regulate food intake.
OBJECTIVE:
The objective was to study the associations between a genetic obesity risk score, appetitive traits, and growth of children up to age 5 years, with a longitudinal design.
METHODS:
In 1142 children from the Etude des Déterminants pre et post natals de la santé de l'ENfant (EDEN) birth cohort, a combined obesity risk-allele score (BMI genetic risk score [GRS]) was related to appetitive traits (energy intake up to 12 mo, a single item on appetite from 4 mo to 3 y, a validated appetite score at 5 y) using Poisson regressions with robust standard errors. The potential mediation of appetitive traits on the association between BMI-GRS and growth was assessed by the Sobel test.
RESULTS:
Children with a high BMI-GRS were more likely to have high energy intake at 1 year and high appetite at 2 and 5 years. High energy intake in infancy and high appetite from 1 year were related to higher subsequent BMI. High 2-year appetite seemed to partially mediate the associations between BMI-GRS and BMI from 2 to 5 years (all P ≤ 0.05).
CONCLUSIONS:
Genetic susceptibility to childhood obesity seems to be partially explained by appetitive traits in infancy, followed by an early childhood rise in BMI.
Cited literature [34 references]
https://www.hal.inserm.fr/inserm-02093066
Contributor : Blandine de Lauzon-Guillain Connect in order to contact the contributor
Submitted on : Monday, April 8, 2019 - 4:08:40 PM
Last modification on : Tuesday, January 18, 2022 - 2:46:04 PM
Long-term archiving on: : Wednesday, July 10, 2019 - 12:38:36 PM
Contributor : Blandine de Lauzon-Guillain Connect in order to contact the contributor
Submitted on : Monday, April 8, 2019 - 4:08:40 PM
Last modification on : Tuesday, January 18, 2022 - 2:46:04 PM
Long-term archiving on: : Wednesday, July 10, 2019 - 12:38:36 PM
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