Drivers of Rift Valley fever epidemics in Madagascar. - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2017

Drivers of Rift Valley fever epidemics in Madagascar.

Résumé

Rift Valley fever (RVF) is a vector-borne viral disease widespread in Africa. The primary cycle involves mosquitoes and wild and domestic ruminant hosts. Humans are usually contaminated after contact with infected ruminants. As many environmental, agricultural, epidemiological, and anthropogenic factors are implicated in RVF spread, the multidisciplinary One Health approach was needed to identify the drivers of RVF epidemics in Madagascar. We examined the environmental patterns associated with these epidemics, comparing human and ruminant serological data with environmental and cattle-trade data. In contrast to East Africa, environmental drivers did not trigger the epidemics: They only modulated local Rift Valley fever virus (RVFV) transmission in ruminants. Instead, RVFV was introduced through ruminant trade and subsequent movement of cattle between trade hubs caused its long-distance spread within the country. Contact with cattle brought in from infected districts was associated with higher infection risk in slaughterhouse workers. The finding that anthropogenic rather than environmental factors are the main drivers of RVF infection in humans can be used to design better prevention and early detection in the case of RVF resurgence in the region.

Domaines

Virologie
Fichier principal
Vignette du fichier
PNAS-2017-Lancelot-938-43.pdf (3.21 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

pasteur-01498224 , version 1 (02-10-2017)

Licence

Copyright (Tous droits réservés)

Identifiants

Citer

Renaud Lancelot, Marina Béral, Vincent Michel Rakotoharinome, Soa-Fy Andriamandimby, Jean-Michel Heraud, et al.. Drivers of Rift Valley fever epidemics in Madagascar.. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (5), pp.938-943. ⟨10.1073/pnas.1607948114⟩. ⟨pasteur-01498224⟩
404 Consultations
203 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More