In this study, we adapted an existing mathematical model (landsepi) to simulate collective deployment scenarios for downy mildew-resistant grapevine cultivars in vine-growing regions. We first used this model to explore the effects of growing cultivars with monogenic and polygenic resistance together in simplified agricultural landscapes, a possibility that is now available to vine-growers. We then applied this model to the Buzet region (a protected designation of origin in South-West France) for the coconstruction, evaluation and comparison of a set of deployment scenarios for the adoption of resistant grapevine cultivars in line with the strategic vision of the "Nous, les vignerons de Buzet" wine co-operative. Finally, we evaluated the effects of these scenarios on epidemic control, resistance durability, the reduction of fungicide treatments and economic performance.